AGO2

The gene Argonaute 2 is referred to in FlyBase by the symbol DmelAGO2 (CG7439, FBgn0087035). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (all unique). Gene sequence location is 3L:15554113..15561042. Its molecular function is described by: endoribonuclease activity, cleaving siRNA-paired mRNA; siRNA binding; endoribonuclease activity; protein binding; single-stranded RNA binding. It is involved in the biological process described with 17 unique terms, many of which group under: multicellular organism development; cellular response to virus; regulation of cellular process; dosage compensation; regulation of viral life cycle. 31 alleles are reported. The phenotypes of these alleles manifest in: nucleus; primordial germ cell; pole bud; condensed chromosome. The phenotypic classes of alleles include: increased mortality; increased mortality during development; phenotype; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.

Argonaute 2

Source FlyBase

Drosophila melanogaster [tax_id: 7227]

dm6