AR

Information AR

Description

This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]

Full Name

androgen receptor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
18
Biotypes
6
Peaks
177,264
Non-redundant peaks
89,654

TF Classification

Familly
Nuclear receptors with C4 zinc fingers
Sub Familly
Steroid hormone receptors (NR3)

Source JASPAR

External IDs

NCBI Gene
11835
Official Gene Name
Ar
JASPAR
MA0007.3
MGI
MGI:88064
Ensembl
ENSMUSG00000046532
UniProt
P19091
Genevisible
P19091
RefSeq
Aliases
AW320017; Tfm

External links
All peaks AR
Download BED file
Non redundant peaks AR
Download BED file
SEQUENCES AR
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for AR

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
AR prostate Foxa1-overexpression GEO Mus musculus GSE128867 134
AR prostate PTEN GEO Mus musculus GSE47119 2,667
AR prostate GEO Mus musculus GSE47119 2,995
AR prostate SPARKI GEO Mus musculus GSE51106 6,321
AR prostate GEO Mus musculus GSE128867 3,209
AR prostate ERG GEO Mus musculus GSE47119 45,897
AR epididymis GEO Mus musculus GSE51106 15,719
AR Hi-Myc prostate-tumor GEO Mus musculus GSE62645 1,558
AR PC17 GEO Mus musculus GSE38656 380
AR prostate GEO Mus musculus GSE51106 7,530
AR prostate PTEN-ERG GEO Mus musculus GSE47119 18,470
AR prostate Foxa1-FE255del GEO Mus musculus GSE128867 537
AR prostate Foxa1-R219S GEO Mus musculus GSE128867 202
AR caput-epididymis ArKl GEO Mus musculus GSE121151 27,262
AR caput-epididymis GEO Mus musculus GSE121151 23,033
AR epididymis SPARKI GEO Mus musculus GSE51106 13,796
AR PC1 GEO Mus musculus GSE38656 373
AR PC17 non-proliferating GEO Mus musculus GSE38656 7,181
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks