ARID1A

Information ARID1A

Description

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

AT-rich interaction domain 1A

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
17
Biotypes
9
Peaks
608,541
Non-redundant peaks
270,799

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
8289
Official Gene Name
ARID1A
JASPAR
Ensembl
ENSG00000117713
UniProt
O14497
Genevisible
O14497
RefSeq
NM_006015
Aliases
B120; BAF250; BAF250a; BM029; C10rf4; C1orf4; CSS2; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1
All peaks ARID1A
Download BED file
Non redundant peaks ARID1A
Download BED file
SEQUENCES ARID1A
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for ARID1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ARID1A MCF-7 GEO Homo sapiens GSE123284 34,276
ARID1A MCF-7 Fulvestrant GEO Homo sapiens GSE123284 47,038
ARID1A MCF-7 JQ1 GEO Homo sapiens GSE123284 33,731
ARID1A HAP1 GEO Homo sapiens GSE108387 24,967
ARID1A MCF-7 4-hydroxytamoxifen GEO Homo sapiens GSE123284 71,527
ARID1A 12Z GEO Homo sapiens GSE129781 79,597
ARID1A NGP GEO Homo sapiens GSE134626 31,292
ARID1A Hep-G2 GEO Homo sapiens GSE69566 16,502
ARID1A LNCaP r1881 GEO Homo sapiens GSE94682 28,264
ARID1A LNCaP GEO Homo sapiens GSE94682 13,287
ARID1A MCF-7 estrogen GEO Homo sapiens GSE123284 16,624
ARID1A MCF-7 DCDT GEO Homo sapiens GSE123284 36,460
ARID1A H9 GEO Homo sapiens GSE139260 7,757
ARID1A RMG-I GEO Homo sapiens GSE120058 30,122
ARID1A RMG-I GEO Homo sapiens GSE104545 45,278
ARID1A endometrial-epithelial-cells KO GEO Homo sapiens GSE106660 33,814
ARID1A endometrial-epithelial-cells GEO Homo sapiens GSE106660 58,005
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks