ARNT
Information ARNT
- Description
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
- Full Name
aryl hydrocarbon receptor nuclear translocator
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 19
- Biotypes
- 15
- Peaks
- 237,110
- Non-redundant peaks
- 131,368
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- PAS domain factors
- Sub Familly
- Arnt-like factors
Source TFClass
External IDs
- NCBI Gene
- 405
- Official Gene Name
- ARNT
- JASPAR
- MA0259
- Ensembl
- ENSG00000143437
- UniProt
- P27540
- Genevisible
- P27540
- RefSeq
- NM_001197325
- Aliases
- HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO; bHLHe2
Datasets Table for ARNT
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ARNT | MCF-7 | aza | GEO | Homo sapiens | GSE85352 | 33,289 | ||
| ARNT | MCF-7 | Ctrl | GEO | Homo sapiens | GSE85352 | 32,516 | ||
| ARNT | RCC4 | GEO | Homo sapiens | GSE85352 | 16,563 | |||
| ARNT | A-549 | GEO | Homo sapiens | GSE85352 | 15,239 | |||
| ARNT | A-549 | GEO | Homo sapiens | GSE130989 | 3,223 | |||
| ARNT | RCC10 | GEO | Homo sapiens | GSE101063 | 1,580 | |||
| ARNT | 501-mel | GEO | Homo sapiens | GSE95280 | 17,757 | |||
| ARNT | SK-MEL-28 | GEO | Homo sapiens | GSE85352 | 35,770 | |||
| ARNT | PC-3 | GEO | Homo sapiens | GSE130989 | 4,087 | |||
| ARNT | T-47D | GEO | Homo sapiens | GSE130989 | 7,715 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR613NUC | 26,659 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR155KHM | 12,277 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR669NFS | 2,130 | |||
| ARNT | Hep-G2 | ENCODE | Homo sapiens | ENCSR029IBC | 1,150 | |||
| ARNT | HUVEC-C | GEO | Homo sapiens | GSE89836 | 543 | |||
| ARNT | HEK293T | ENCODE | Homo sapiens | ENCSR760UKJ | 1,501 | |||
| ARNT | GM12878 | ENCODE | Homo sapiens | ENCSR590KEQ | 15,531 | |||
| ARNT | 786-M1A | GEO | Homo sapiens | GSE98012 | 443 | |||
| ARNT | HCT-116 | GEO | Homo sapiens | GSE130989 | 9,137 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |