ASCL1
Information ASCL1
- Description
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). {ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:18173746, ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220, ECO:0000269|PubMed:8217843, ECO:0000269|PubMed:8221886}.(Source UnitProtKB).
- Full Name
achaete-scute family bHLH transcription factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 9
- Biotypes
- 7
- Peaks
- 143,055
- Non-redundant peaks
- 98,853
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for ASCL1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
ASCL1 | MEF | 48h | GEO | Mus musculus | GSE43916 | 6,988 | ||
ASCL1 | MEF | BAM | GEO | Mus musculus | GSE43916 | 5,513 | ||
ASCL1 | EBs | GEO | Mus musculus | GSE114172 | 8,905 | |||
ASCL1 | lung-tumor | GEO | Mus musculus | GSE69394 | 2,742 | |||
ASCL1 | NPC | GEO | Mus musculus | GSE43916 | 32,269 | |||
ASCL1 | spinal-cord | GEO | Mus musculus | GSE43159 | 2,910 | |||
ASCL1 | mESC | 24h | GEO | Mus musculus | GSE97712 | 2,425 | ||
ASCL1 | EBs | Dox-48H | GEO | Mus musculus | GSE114172 | 68,923 | ||
ASCL1 | AtT-20 | GEO | Mus musculus | GSE64483 | 12,380 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |