ASCL1

Information ASCL1

Description

Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). {ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:18173746, ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220, ECO:0000269|PubMed:8217843, ECO:0000269|PubMed:8221886}.(Source UnitProtKB).

Full Name

achaete-scute family bHLH transcription factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
9
Biotypes
7
Peaks
143,055
Non-redundant peaks
98,853

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
17172
Official Gene Name
Ascl1
JASPAR
MGI
MGI:96919
Ensembl
ENSMUSG00000020052
UniProt
Q02067
Genevisible
Q02067
RefSeq
NM_008553
Aliases
AI225900; ASH1; Mash1; bHLHa46
All peaks ASCL1
Download BED file
Non redundant peaks ASCL1
Download BED file
SEQUENCES ASCL1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for ASCL1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ASCL1 MEF 48h GEO Mus musculus GSE43916 6,988
ASCL1 MEF BAM GEO Mus musculus GSE43916 5,513
ASCL1 EBs GEO Mus musculus GSE114172 8,905
ASCL1 lung-tumor GEO Mus musculus GSE69394 2,742
ASCL1 NPC GEO Mus musculus GSE43916 32,269
ASCL1 spinal-cord GEO Mus musculus GSE43159 2,910
ASCL1 mESC 24h GEO Mus musculus GSE97712 2,425
ASCL1 EBs Dox-48H GEO Mus musculus GSE114172 68,923
ASCL1 AtT-20 GEO Mus musculus GSE64483 12,380
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks