ATF2

Information ATF2

Description

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

Full Name

activating transcription factor 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
6
Peaks
259,152
Non-redundant peaks
164,009

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1386
Official Gene Name
ATF2
JASPAR
Ensembl
ENSG00000115966
UniProt
P15336
Genevisible
P15336
RefSeq
NM_001256090
Aliases
CRE-BP1; CREB-2; CREB2; HB16; TREB7
All peaks ATF2
Download BED file
Non redundant peaks ATF2
Download BED file
SEQUENCES ATF2
Download FASTA file
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Datasets Table for ATF2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ATF2 macrophage GEO Homo sapiens GSE80727 7,808
ATF2 WA01 ENCODE Homo sapiens ENCSR000BQU 43,740
ATF2 K-562 ENCODE Homo sapiens ENCSR869IUD 51,760
ATF2 Hep-G2 ENCODE Homo sapiens ENCSR047BUZ 70,173
ATF2 HEK293 ENCODE Homo sapiens ENCSR217HTK 33,987
ATF2 GM12878 ENCODE Homo sapiens ENCSR961PPA 18,698
ATF2 GM12878 ENCODE Homo sapiens ENCSR000BQK 32,986
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks