ATF7
Information ATF7
- Description
Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as Htr5b, STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (PubMed:19893493, PubMed:31294895, PubMed:30826729). Phosphorylation of ATF7 disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (PubMed:19893493). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (PubMed:31958521). {ECO:0000269|PubMed:19893493, ECO:0000269|PubMed:29490055, ECO:0000269|PubMed:30826729, ECO:0000269|PubMed:31294895, ECO:0000269|PubMed:31958521}.(Source UnitProtKB).
- Full Name
activating transcription factor 7
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 31,150
- Non-redundant peaks
- 31,150
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 223922
- Official Gene Name
- Atf7
- JASPAR
- MGI
- MGI:2443472
- Ensembl
- ENSMUSG00000099083
- UniProt
- Q8R0S1
- Genevisible
- Q8R0S1
- RefSeq
- NM_001310070
- Aliases
- 1110012F10Rik; 9430065F09Rik; C130020M04Rik