ATF7

Information ATF7

Description

Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as Htr5b, STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (PubMed:19893493, PubMed:31294895, PubMed:30826729). Phosphorylation of ATF7 disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (PubMed:19893493). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (PubMed:31958521). {ECO:0000269|PubMed:19893493, ECO:0000269|PubMed:29490055, ECO:0000269|PubMed:30826729, ECO:0000269|PubMed:31294895, ECO:0000269|PubMed:31958521}.(Source UnitProtKB).

Full Name

activating transcription factor 7

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
31,150
Non-redundant peaks
31,150

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
223922
Official Gene Name
Atf7
JASPAR
MGI
MGI:2443472
Ensembl
ENSMUSG00000099083
UniProt
Q8R0S1
Genevisible
Q8R0S1
RefSeq
NM_001310070
Aliases
1110012F10Rik; 9430065F09Rik; C130020M04Rik
All peaks ATF7
Download BED file
Non redundant peaks ATF7
Download BED file
SEQUENCES ATF7
Download FASTA file
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Datasets Table for ATF7

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ATF7 3T3-L1 GEO Mus musculus GSE56872 31,150
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks