ATF7IP
Information ATF7IP
- Description
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity). {ECO:0000250|UniProtKB:Q6VMQ6, ECO:0000269|PubMed:10777215, ECO:0000269|PubMed:14536086}.(Source UnitProtKB).
- Full Name
activating transcription factor 7 interacting protein
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 5,597
- Non-redundant peaks
- 5,597
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 54343
- Official Gene Name
- Atf7ip
- JASPAR
- MGI
- MGI:1858965
- Ensembl
- ENSMUSG00000030213
- UniProt
- Q7TT18
- Genevisible
- Q7TT18
- RefSeq
- Aliases
- 2610204M12Rik; AM; ATFa-associated Modulator; Mcaf1