BAP1

Information BAP1

Description

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. {ECO:0000250|UniProtKB:Q92560}.(Source UnitProtKB).

Full Name

Brca1 associated protein 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
42,936
Non-redundant peaks
31,397

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
104416
Official Gene Name
Bap1
JASPAR
MGI
MGI:1206586
Ensembl
ENSMUSG00000021901
UniProt
Q99PU7
Genevisible
Q99PU7
RefSeq
NM_027088
Aliases
2300006C11Rik
All peaks BAP1
Download BED file
Non redundant peaks BAP1
Download BED file
SEQUENCES BAP1
Download FASTA file
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Datasets Table for BAP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
BAP1 mESC KO GEO Mus musculus GSE105006 7,505
BAP1 mESC GEO Mus musculus GSE105006 19,880
BAP1 BMDM GEO Mus musculus GSE40723 15,551
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks