BAP1
Information BAP1
- Description
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. {ECO:0000250|UniProtKB:Q92560}.(Source UnitProtKB).
- Full Name
Brca1 associated protein 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 42,936
- Non-redundant peaks
- 31,397
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 104416
- Official Gene Name
- Bap1
- JASPAR
- MGI
- MGI:1206586
- Ensembl
- ENSMUSG00000021901
- UniProt
- Q99PU7
- Genevisible
- Q99PU7
- RefSeq
- NM_027088
- Aliases
- 2300006C11Rik
Datasets Table for BAP1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
BAP1 | mESC | KO | GEO | Mus musculus | GSE105006 | 7,505 | ||
BAP1 | mESC | GEO | Mus musculus | GSE105006 | 19,880 | |||
BAP1 | BMDM | GEO | Mus musculus | GSE40723 | 15,551 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |