BAP1

Information BAP1

Description

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Full Name

BRCA1 associated protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
6
Biotypes
3
Peaks
34,433
Non-redundant peaks
27,087

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
8314
Official Gene Name
BAP1
JASPAR
Ensembl
ENSG00000163930
UniProt
Q92560
Genevisible
Q92560
RefSeq
NM_004656
Aliases
HUCEP-13; KIAA0272; UCHL2; hucep-6
All peaks BAP1
Download BED file
Non redundant peaks BAP1
Download BED file
SEQUENCES BAP1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for BAP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
BAP1 UM-RC-6 GEO Homo sapiens GSE101987 1,695
BAP1 UM-RC-6 empty-vector GEO Homo sapiens GSE101987 1,459
BAP1 UM-RC-6 BAP1-C91A-mutant GEO Homo sapiens GSE101987 1,647
BAP1 PANC-1 GEO Homo sapiens GSE120460 3,963
BAP1 NCI-H1963 shASXL3 GEO Homo sapiens GSE145028 12,547
BAP1 NCI-H1963 shNONT GEO Homo sapiens GSE145028 13,122
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks