BATF

Information BATF

Description

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs. {ECO:0000269|PubMed:11466704, ECO:0000269|PubMed:12594265, ECO:0000269|PubMed:19578362, ECO:0000269|PubMed:20421391, ECO:0000269|PubMed:21572431, ECO:0000269|PubMed:22001828, ECO:0000269|PubMed:22385964, ECO:0000269|PubMed:22983707, ECO:0000269|PubMed:22992523, ECO:0000269|PubMed:22992524, ECO:0000269|PubMed:23021777}.(Source UnitProtKB).

Full Name

basic leucine zipper transcription factor, ATF-like

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
18
Biotypes
8
Peaks
488,082
Non-redundant peaks
163,353

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
53314
Official Gene Name
Batf
JASPAR
MGI
MGI:1859147
Ensembl
ENSMUSG00000034266
UniProt
O35284
Genevisible
O35284
RefSeq
NM_016767
Aliases
B-ATF; SFA-2
All peaks BATF
Download BED file
Non redundant peaks BATF
Download BED file
SEQUENCES BATF
Download FASTA file
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Datasets Table for BATF

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
BATF spleen 72h GEO Mus musculus GSE116205 28,407
BATF spleen 0h GEO Mus musculus GSE116205 3,691
BATF spleen GEO Mus musculus GSE99165 557
BATF CD4-pos vec GEO Mus musculus GSE132476 2,008
BATF BMDC GEO Mus musculus GSE52772 3,623
BATF Th17 16h GEO Mus musculus GSE40918 45,490
BATF Th17 42h GEO Mus musculus GSE40727 32,677
BATF Th17 GEO Mus musculus GSE39756 20,160
BATF Th17 GEO Mus musculus GSE40918 39,707
BATF lymphocyte Treg GEO Mus musculus GSE121294 19,273
BATF CD8-pos GEO Mus musculus GSE54191 2,475
BATF Th0 GEO Mus musculus GSE40918 69,778
BATF Th0 IRF4-WT_48h GEO Mus musculus GSE40918 36,202
BATF Th0 IRF4-KO_48h GEO Mus musculus GSE40918 38,267
BATF Th2 GEO Mus musculus GSE85172 29,434
BATF CD4-pos GEO Mus musculus GSE132476 5,257
BATF spleen Tet2-3-KO_72h GEO Mus musculus GSE116205 32,630
BATF Th17 IRF4-KO_48h GEO Mus musculus GSE40918 78,446
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks