BATF
Information BATF
- Description
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs. {ECO:0000269|PubMed:11466704, ECO:0000269|PubMed:12594265, ECO:0000269|PubMed:19578362, ECO:0000269|PubMed:20421391, ECO:0000269|PubMed:21572431, ECO:0000269|PubMed:22001828, ECO:0000269|PubMed:22385964, ECO:0000269|PubMed:22983707, ECO:0000269|PubMed:22992523, ECO:0000269|PubMed:22992524, ECO:0000269|PubMed:23021777}.(Source UnitProtKB).
- Full Name
basic leucine zipper transcription factor, ATF-like
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 18
- Biotypes
- 8
- Peaks
- 488,082
- Non-redundant peaks
- 163,353
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 53314
- Official Gene Name
- Batf
- JASPAR
- MGI
- MGI:1859147
- Ensembl
- ENSMUSG00000034266
- UniProt
- O35284
- Genevisible
- O35284
- RefSeq
- NM_016767
- Aliases
- B-ATF; SFA-2
Datasets Table for BATF
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
BATF | spleen | 72h | GEO | Mus musculus | GSE116205 | 28,407 | ||
BATF | spleen | 0h | GEO | Mus musculus | GSE116205 | 3,691 | ||
BATF | spleen | GEO | Mus musculus | GSE99165 | 557 | |||
BATF | CD4-pos | vec | GEO | Mus musculus | GSE132476 | 2,008 | ||
BATF | BMDC | GEO | Mus musculus | GSE52772 | 3,623 | |||
BATF | Th17 | 16h | GEO | Mus musculus | GSE40918 | 45,490 | ||
BATF | Th17 | 42h | GEO | Mus musculus | GSE40727 | 32,677 | ||
BATF | Th17 | GEO | Mus musculus | GSE39756 | 20,160 | |||
BATF | Th17 | GEO | Mus musculus | GSE40918 | 39,707 | |||
BATF | lymphocyte | Treg | GEO | Mus musculus | GSE121294 | 19,273 | ||
BATF | CD8-pos | GEO | Mus musculus | GSE54191 | 2,475 | |||
BATF | Th0 | GEO | Mus musculus | GSE40918 | 69,778 | |||
BATF | Th0 | IRF4-WT_48h | GEO | Mus musculus | GSE40918 | 36,202 | ||
BATF | Th0 | IRF4-KO_48h | GEO | Mus musculus | GSE40918 | 38,267 | ||
BATF | Th2 | GEO | Mus musculus | GSE85172 | 29,434 | |||
BATF | CD4-pos | GEO | Mus musculus | GSE132476 | 5,257 | |||
BATF | spleen | Tet2-3-KO_72h | GEO | Mus musculus | GSE116205 | 32,630 | ||
BATF | Th17 | IRF4-KO_48h | GEO | Mus musculus | GSE40918 | 78,446 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |