BCL11B
Information BCL11B
- Description
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. {ECO:0000250|UniProtKB:Q9C0K0, ECO:0000269|PubMed:12717433, ECO:0000269|PubMed:16809611}.(Source UnitProtKB).
- Full Name
B cell leukemia/lymphoma 11B
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 14
- Biotypes
- 6
- Peaks
- 500,917
- Non-redundant peaks
- 216,418
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 58208
- Official Gene Name
- Bcl11b
- JASPAR
- MGI
- MGI:1929913
- Ensembl
- ENSMUSG00000048251
- UniProt
- Q99PV8
- Genevisible
- Q99PV8
- RefSeq
- NM_021399
- Aliases
- 9130430L19Rik; B630002E05Rik; COUP-TF interacting protein 2; CTIP2; Rit1
Datasets Table for BCL11B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| BCL11B | BM-derived-DN3 | GEO | Mus musculus | GSE93572 | 70,934 | |||
| BCL11B | CD4-pos | Foxp3-KO | GEO | Mus musculus | GSE120947 | 4,228 | ||
| BCL11B | CD4-pos | Treg-cells | GEO | Mus musculus | GSE120947 | 6,174 | ||
| BCL11B | CD4-pos | Bcl11b-KO | GEO | Mus musculus | GSE120873 | 788 | ||
| BCL11B | CD4-pos | GEO | Mus musculus | GSE99597 | 54,799 | |||
| BCL11B | thymocyte | GEO | Mus musculus | GSE99597 | 30,516 | |||
| BCL11B | thymocyte | EGS | GEO | Mus musculus | GSE79874 | 36,238 | ||
| BCL11B | pro-T-cell | GEO | Mus musculus | GSE131082 | 63,125 | |||
| BCL11B | bone-marrow | GEO | Mus musculus | GSE110305 | 74,121 | |||
| BCL11B | bone-marrow | bcl11-KO | GEO | Mus musculus | GSE110305 | 13,669 | ||
| BCL11B | CD4-pos | GEO | Mus musculus | GSE120873 | 8,792 | |||
| BCL11B | CD4-pos | Tn-cells | GEO | Mus musculus | GSE120947 | 12,939 | ||
| BCL11B | ILC2 | GEO | Mus musculus | GSE131082 | 61,161 | |||
| BCL11B | thymocyte | ThPOKgfpTESPE | GEO | Mus musculus | GSE90949 | 63,433 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |