BMI1

Information BMI1

Description

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

Full Name

BMI1 proto-oncogene, polycomb ring finger

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
5
Biotypes
5
Peaks
37,764
Non-redundant peaks
32,681

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
648
Official Gene Name
BMI1
JASPAR
Ensembl
ENSG00000168283
UniProt
P35226
Genevisible
P35226
RefSeq
NM_005180
Aliases
FLVI2/BMI1; PCGF4; RNF51; flvi-2/bmi-1
All peaks BMI1
Download BED file
Non redundant peaks BMI1
Download BED file
SEQUENCES BMI1
Download FASTA file
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Datasets Table for BMI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
BMI1 HEK293T GEO Homo sapiens GSE34774 54
BMI1 MCF-7 ENCODE Homo sapiens ENCSR966YYJ 14,325
BMI1 K-562 ENCODE Homo sapiens ENCSR782WRO 10,348
BMI1 GM12878 ENCODE Homo sapiens ENCSR469WII 12,893
BMI1 LNCaP-C4-2 GEO Homo sapiens GSE97831 144
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks