CBFA2T2

Information CBFA2T2

Description

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). {ECO:0000250|UniProtKB:O43439, ECO:0000269|PubMed:16227606, ECO:0000269|PubMed:25398765, ECO:0000269|PubMed:27281218}.(Source UnitProtKB).

Full Name

CBFA2/RUNX1 translocation partner 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
5
Biotypes
2
Peaks
7,270
Non-redundant peaks
4,896

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
12396
Official Gene Name
Cbfa2t2
JASPAR
MGI
MGI:1333833
Ensembl
ENSMUSG00000038533
UniProt
O70374
Genevisible
O70374
RefSeq
NM_172860
Aliases
A430091M07; C330013D05Rik; Cbfa2t2h; MTGR1
All peaks CBFA2T2
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Non redundant peaks CBFA2T2
Download BED file
SEQUENCES CBFA2T2
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Datasets Table for CBFA2T2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CBFA2T2 KH2 GEO Mus musculus GSE71675 274
CBFA2T2 mESC Prdm14-rescue GEO Mus musculus GSE74547 2,788
CBFA2T2 mESC GEO Mus musculus GSE74547 2,514
CBFA2T2 mESC Cbfa2-null GEO Mus musculus GSE74547 866
CBFA2T2 mESC Prdm14-null GEO Mus musculus GSE74547 828
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks