CBFA2T2

Information CBFA2T2

Description

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Full Name

CBFA2/RUNX1 partner transcriptional co-repressor 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
65,366
Non-redundant peaks
64,070

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
9139
Official Gene Name
CBFA2T2
JASPAR
Ensembl
ENSG00000078699
UniProt
O43439
Genevisible
O43439
RefSeq
NM_001032999
Aliases
EHT; MTGR1; ZMYND3; p85
All peaks CBFA2T2
Download BED file
Non redundant peaks CBFA2T2
Download BED file
SEQUENCES CBFA2T2
Download FASTA file
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Datasets Table for CBFA2T2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CBFA2T2 NCCIT GEO Homo sapiens GSE71675 38,711
CBFA2T2 K-562 ENCODE Homo sapiens ENCSR699PVC 26,655
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks