CBFB

Information CBFB

Description

Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). {ECO:0000269|PubMed:18258917, ECO:0000305|PubMed:11257229, ECO:0000305|PubMed:8386878, ECO:0000305|PubMed:8497254}.(Source UnitProtKB).

Full Name

core binding factor beta

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
14
Biotypes
7
Peaks
353,164
Non-redundant peaks
130,992

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
12400
Official Gene Name
Cbfb
JASPAR
MGI
MGI:99851
Ensembl
ENSMUSG00000031885
UniProt
Q08024
Genevisible
Q08024
RefSeq
NM_022309
Aliases
AI893578; PEA2; PEBP2b; Pebp2; Pebpb2
All peaks CBFB
Download BED file
Non redundant peaks CBFB
Download BED file
SEQUENCES CBFB
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for CBFB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CBFB CD4-pos GEO Mus musculus GSE130599 30,288
CBFB liver E12-5_lin-neg_CBFB1 GEO Mus musculus GSE90794 23,269
CBFB thymocyte GEO Mus musculus GSE33653 3,961
CBFB thymocyte pan-CBFB GEO Mus musculus GSE90794 56,012
CBFB lung IL33 GEO Mus musculus GSE111871 9,313
CBFB CD8-pos GEO Mus musculus GSE130599 37,038
CBFB CD8 effector GEO Mus musculus GSE81887 11,776
CBFB L8057 induced GEO Mus musculus GSE33653 12,992
CBFB L8057 uninduced GEO Mus musculus GSE33653 7,036
CBFB CD8 GEO Mus musculus GSE81887 11,341
CBFB lung GEO Mus musculus GSE111871 13,125
CBFB thymocyte CBFB1 GEO Mus musculus GSE90794 57,934
CBFB liver E12-5_lin-neg_CBFB2 GEO Mus musculus GSE90794 25,872
CBFB liver E12-5_lin-neg_pan-CBFB GEO Mus musculus GSE90794 53,207
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks