CBFB
Information CBFB
- Description
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). {ECO:0000269|PubMed:18258917, ECO:0000305|PubMed:11257229, ECO:0000305|PubMed:8386878, ECO:0000305|PubMed:8497254}.(Source UnitProtKB).
- Full Name
core binding factor beta
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 14
- Biotypes
- 7
- Peaks
- 353,164
- Non-redundant peaks
- 130,992
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for CBFB
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
CBFB | CD4-pos | GEO | Mus musculus | GSE130599 | 30,288 | |||
CBFB | liver | E12-5_lin-neg_CBFB1 | GEO | Mus musculus | GSE90794 | 23,269 | ||
CBFB | thymocyte | GEO | Mus musculus | GSE33653 | 3,961 | |||
CBFB | thymocyte | pan-CBFB | GEO | Mus musculus | GSE90794 | 56,012 | ||
CBFB | lung | IL33 | GEO | Mus musculus | GSE111871 | 9,313 | ||
CBFB | CD8-pos | GEO | Mus musculus | GSE130599 | 37,038 | |||
CBFB | CD8 | effector | GEO | Mus musculus | GSE81887 | 11,776 | ||
CBFB | L8057 | induced | GEO | Mus musculus | GSE33653 | 12,992 | ||
CBFB | L8057 | uninduced | GEO | Mus musculus | GSE33653 | 7,036 | ||
CBFB | CD8 | GEO | Mus musculus | GSE81887 | 11,341 | |||
CBFB | lung | GEO | Mus musculus | GSE111871 | 13,125 | |||
CBFB | thymocyte | CBFB1 | GEO | Mus musculus | GSE90794 | 57,934 | ||
CBFB | liver | E12-5_lin-neg_CBFB2 | GEO | Mus musculus | GSE90794 | 25,872 | ||
CBFB | liver | E12-5_lin-neg_pan-CBFB | GEO | Mus musculus | GSE90794 | 53,207 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |