CBX3
Information CBX3
- Description
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity). {ECO:0000250|UniProtKB:Q13185, ECO:0000269|PubMed:24413057}.
- Full Name
chromobox 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 85,001
- Non-redundant peaks
- 81,403
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 12417
- Official Gene Name
- Cbx3
- JASPAR
- MGI
- MGI:108515
- Ensembl
- ENSMUSG00000029836
- UniProt
- P23198
- Genevisible
- P23198
- RefSeq
- Aliases
- HP1g; M32; heterochromatin protein 1 gamma
Datasets Table for CBX3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CBX3 | pre-iPSC | GEO | Mus musculus | GSE44242 | 70,259 | |||
| CBX3 | mESC | GEO | Mus musculus | GSE44242 | 14,742 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |