CD74
Information CD74
- Description
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
- Full Name
CD74 molecule
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 1
- Peaks
- 18,324
- Non-redundant peaks
- 11,732
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 972
- Official Gene Name
- CD74
- JASPAR
- Ensembl
- ENSG00000019582
- UniProt
- P04233
- Genevisible
- P04233
- RefSeq
- NM_001025158
- Aliases
- DHLAG; HLADG; II; Ia-GAMMA; p33
Datasets Table for CD74
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CD74 | CLL | p1 | GEO | Homo sapiens | GSE88955 | 5,639 | ||
| CD74 | CLL | p2 | GEO | Homo sapiens | GSE88955 | 1,794 | ||
| CD74 | CLL | p3 | GEO | Homo sapiens | GSE88955 | 1,921 | ||
| CD74 | CLL | p4 | GEO | Homo sapiens | GSE88955 | 8,970 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |