CDK8

Information CDK8

Description

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Full Name

cyclin dependent kinase 8

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
22
Biotypes
10
Peaks
388,822
Non-redundant peaks
204,893

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1024
Official Gene Name
CDK8
JASPAR
Ensembl
ENSG00000132964
UniProt
P49336
Genevisible
P49336
RefSeq
NM_001260
Aliases
K35
All peaks CDK8
Download BED file
Non redundant peaks CDK8
Download BED file
SEQUENCES CDK8
Download FASTA file
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Datasets Table for CDK8

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CDK8 MV4-11 GEO Homo sapiens GSE65138 5,664
CDK8 SET-2 GEO Homo sapiens GSE65138 26,973
CDK8 monocyte IFNg GEO Homo sapiens GSE120943 8,472
CDK8 monocyte IFNg-LPS GEO Homo sapiens GSE120943 9,204
CDK8 monocyte LPS GEO Homo sapiens GSE120943 6,375
CDK8 monocyte resting GEO Homo sapiens GSE120943 1,256
CDK8 MOLM-14 GEO Homo sapiens GSE65138 24,685
CDK8 MOLM-14 IBET GEO Homo sapiens GSE65138 56,689
CDK8 leiomyoma PT967 GEO Homo sapiens GSE128230 14,948
CDK8 leiomyoma PT916 GEO Homo sapiens GSE128230 5,985
CDK8 leiomyoma PT1063 GEO Homo sapiens GSE128230 7,114
CDK8 leiomyoma PT886 GEO Homo sapiens GSE128230 67,017
CDK8 leiomyoma PT848 GEO Homo sapiens GSE128230 11,773
CDK8 K-562 GEO Homo sapiens GSE65138 2,111
CDK8 SW480 GEO Homo sapiens GSE53602 12,706
CDK8 myometrium PT1063 GEO Homo sapiens GSE128230 22,592
CDK8 myometrium PT916 GEO Homo sapiens GSE128230 28,064
CDK8 myometrium PT848 GEO Homo sapiens GSE128230 10,789
CDK8 myometrium PT886 GEO Homo sapiens GSE128230 24,590
CDK8 myometrium PT967 GEO Homo sapiens GSE128230 15,274
CDK8 MM1-S GEO Homo sapiens GSE43743 3,760
CDK8 HCT-116 NOMO GEO Homo sapiens GSE38258 22,781
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks