CDKN1B

Information CDKN1B

Description

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Full Name

cyclin dependent kinase inhibitor 1B

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
153,172
Non-redundant peaks
101,840

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1027
Official Gene Name
CDKN1B
JASPAR
Ensembl
ENSG00000111276
UniProt
P46527
Genevisible
P46527
RefSeq
NM_004064
Aliases
CDKN4; KIP1; MEN1B; MEN4; P27KIP1
All peaks CDKN1B
Download BED file
Non redundant peaks CDKN1B
Download BED file
SEQUENCES CDKN1B
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for CDKN1B

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CDKN1B MDA-BoM-1833 shp27 GEO Homo sapiens GSE112444 13,289
CDKN1B MDA-MB-231 GEO Homo sapiens GSE112444 61,402
CDKN1B MDA-MB-231 p27CK-DD GEO Homo sapiens GSE112444 78,481
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks