CDKN1B
Information CDKN1B
- Description
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
- Full Name
cyclin dependent kinase inhibitor 1B
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 153,172
- Non-redundant peaks
- 101,840
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for CDKN1B
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
CDKN1B | MDA-BoM-1833 | shp27 | GEO | Homo sapiens | GSE112444 | 13,289 | ||
CDKN1B | MDA-MB-231 | GEO | Homo sapiens | GSE112444 | 61,402 | |||
CDKN1B | MDA-MB-231 | p27CK-DD | GEO | Homo sapiens | GSE112444 | 78,481 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |