CDX2
Information CDX2
- Description
Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:9933478, PubMed:16027724). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (PubMed:7935448). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (PubMed:9933478). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (PubMed:16027724). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (PubMed:9512360). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity). {ECO:0000250|UniProtKB:Q04649, ECO:0000250|UniProtKB:Q99626, ECO:0000269|PubMed:16027724, ECO:0000269|PubMed:7935448, ECO:0000269|PubMed:9512360, ECO:0000269|PubMed:9933478}.(Source UnitProtKB).
- Full Name
caudal type homeobox 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 20
- Biotypes
- 10
- Peaks
- 344,820
- Non-redundant peaks
- 184,803
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for CDX2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CDX2 | intestine | villus-cells | GEO | Mus musculus | GSE24633 | 4,514 | ||
| CDX2 | E8-5 | GEO | Mus musculus | GSE128858 | 2,723 | |||
| CDX2 | intestinal-villus-epithelial-cell | GEO | Mus musculus | GSE115541 | 22,136 | |||
| CDX2 | villus | HNF4A-KO | GEO | Mus musculus | GSE34566 | 508 | ||
| CDX2 | mESC | trunc | GEO | Mus musculus | GSE39435 | 63,126 | ||
| CDX2 | mESC | GEO | Mus musculus | GSE90752 | 464 | |||
| CDX2 | mESC | TSC | GEO | Mus musculus | GSE90752 | 8,151 | ||
| CDX2 | mESC | truncated | GEO | Mus musculus | GSE39435 | 73,408 | ||
| CDX2 | mESC | E14 | GEO | Mus musculus | GSE115541 | 7,154 | ||
| CDX2 | EpiSC | GEO | Mus musculus | GSE84899 | 14,739 | |||
| CDX2 | progenitor-motor-neuron | GEO | Mus musculus | GSE39433 | 22,683 | |||
| CDX2 | villus | GEO | Mus musculus | GSE34566 | 688 | |||
| CDX2 | midgut | E13-5 | GEO | Mus musculus | GSE115314 | 860 | ||
| CDX2 | intestinal-villus-epithelial-cell | WT | GEO | Mus musculus | GSE98724 | 59,655 | ||
| CDX2 | fibroblast | GEO | Mus musculus | GSE119782 | 195 | |||
| CDX2 | mESC | FGF | GEO | Mus musculus | GSE39435 | 1,222 | ||
| CDX2 | mESC | GEO | Mus musculus | GSE39435 | 19,614 | |||
| CDX2 | midgut | E17-5 | GEO | Mus musculus | GSE115314 | 20,236 | ||
| CDX2 | midgut | adult | GEO | Mus musculus | GSE115314 | 13,355 | ||
| CDX2 | endoderm | GEO | Mus musculus | GSE39435 | 9,389 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |