Information CEBPB


Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:9727068, PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764). The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:9727068, PubMed:10635333, PubMed:16585579). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205). Together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P17676, ECO:0000250|UniProtKB:P21272, ECO:0000269|PubMed:10635333, ECO:0000269|PubMed:1314426, ECO:0000269|PubMed:15509779, ECO:0000269|PubMed:15985551, ECO:0000269|PubMed:16585579, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:17601773, ECO:0000269|PubMed:17911624, ECO:0000269|PubMed:18486321, ECO:0000269|PubMed:19440205, ECO:0000269|PubMed:19478079, ECO:0000269|PubMed:20111005, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:24061474, ECO:0000269|PubMed:24216764, ECO:0000269|PubMed:9303532, ECO:0000269|PubMed:9727068, ECO:0000303|PubMed:25451943}.; [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000269|PubMed:17911624}.; [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (By similarity). Promotes osteoblast differentiation and osteoclastogenesis (PubMed:19440205). {ECO:0000250|UniProtKB:P17676, ECO:0000250|UniProtKB:P21272, ECO:0000269|PubMed:19440205}.(Source UnitProtKB).

Full Name

CCAAT/enhancer binding protein (C/EBP), beta

Source UniprotKB


Mus musculus [tax_id: 10090]



ReMap Statistics

Non-redundant peaks

TF Classification

Sub Familly


External IDs

Official Gene Name
All peaks CEBPB
Download BED file
Non redundant peaks CEBPB
Download BED file
Download FASTA file
Got to catalogue

Datasets Table for CEBPB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CEBPB liver fed GEO Mus musculus GSE72084 49,226
CEBPB liver GEO Mus musculus GSE45674 56,153
CEBPB liver FoxAflox_Alfp-Cre GEO Mus musculus GSE77670 1,717
CEBPB liver vehicle-3h GEO Mus musculus GSE121915 47,797
CEBPB liver prednisolone GEO Mus musculus GSE59752 56,581
CEBPB myocyte ENCODE Mus musculus ENCSR000AIB 29,020
CEBPB MEF GEO Mus musculus GSE90893 78,280
CEBPB MEF 48h GEO Mus musculus GSE90893 55,194
CEBPB primary-hepatocyte IL-1 GEO Mus musculus GSE96767 16,251
CEBPB pre-B-cell 12h GEO Mus musculus GSE53362 1,911
CEBPB pre-B-cell 24h GEO Mus musculus GSE53362 5,639
CEBPB pre-B-cell 0h GEO Mus musculus GSE53362 216
CEBPB pre-B-cell 3h GEO Mus musculus GSE53362 6,232
CEBPB BMDC 30min GEO Mus musculus GSE36099 35,038
CEBPB BMDC 1h GEO Mus musculus GSE36099 25,610
CEBPB mpkCCD vehicle GEO Mus musculus GSE98076 5,123
CEBPB C2C12 ENCODE Mus musculus ENCSR000AIV 29,570
CEBPB MSC veh_d7 GEO Mus musculus GSE79813 40,646
CEBPB brown-adipocyte d0 GEO Mus musculus GSE83757 5,920
CEBPB brown-adipocyte d6 GEO Mus musculus GSE83757 28,889
CEBPB immortalized-brown-preadipocyte Vec-GFP GEO Mus musculus GSE50455 65,146
CEBPB immortalized-brown-preadipocyte Vec-Cre GEO Mus musculus GSE50455 37,082
CEBPB immortalized-brown-preadipocyte Cre GEO Mus musculus GSE50455 68,084
CEBPB brown-preadipocyte D3 GEO Mus musculus GSE74189 10,302
CEBPB brown-preadipocyte D0 GEO Mus musculus GSE74189 18,382
CEBPB 3T3-L1 Dox_BYK GEO Mus musculus GSE85100 3,224
CEBPB 3T3-L1 Dox GEO Mus musculus GSE85100 1,212
CEBPB 3T3-L1 GEO Mus musculus GSE85100 1,297
CEBPB 3T3-L1 GEO Mus musculus GSE21898 5,804
CEBPB 32D bone-marrow GEO Mus musculus GSE100487 5,613
CEBPB bone-marrow moDC GEO Mus musculus GSE62702 62,270
CEBPB bone-marrow Ly6Clo GEO Mus musculus GSE80031 22,949
CEBPB BV-2 pCDH GEO Mus musculus GSE54443 36,984
CEBPB BV-2 Nmu GEO Mus musculus GSE54443 45,621
CEBPB BV-2 Nwt GEO Mus musculus GSE54443 75,830
CEBPB BMDM KLA_SPRET GEO Mus musculus GSE109965 55,067
CEBPB BMDM 15min GEO Mus musculus GSE99895 17,520
CEBPB BMDM KLA_B6 GEO Mus musculus GSE109965 56,356
CEBPB BMDM 1h GEO Mus musculus GSE99895 18,456
CEBPB BMDM 0min GEO Mus musculus GSE99895 18,775
CEBPB BMDM PWK GEO Mus musculus GSE109965 55,263
CEBPB BMDM KLA_NOD GEO Mus musculus GSE109965 65,935
CEBPB BMDM KLA GEO Mus musculus GSE109965 65,015
CEBPB BMDM IFNg-IL4-4h GEO Mus musculus GSE84518 7,938
CEBPB BMDM SPRET GEO Mus musculus GSE109965 26,652
CEBPB BMDM B6 GEO Mus musculus GSE109965 58,852
CEBPB BMDM KLA_PWK GEO Mus musculus GSE109965 73,363
CEBPB BMDM GEO Mus musculus GSE109965 66,877
CEBPB BMDM UT GEO Mus musculus GSE84518 6,316
CEBPB BMDM 2h GEO Mus musculus GSE99895 34,277
CEBPB primary-macrophage GEO Mus musculus GSE21314 32,951
CEBPB pre-iPSC GEO Mus musculus GSE90893 25,861
CEBPB brown-preadipocyte vec-4h GEO Mus musculus GSE76619 59,282
CEBPB brown-preadipocyte D2 GEO Mus musculus GSE74189 79,443
CEBPB brown-preadipocyte D7 GEO Mus musculus GSE74189 30,410
CEBPB bone-marrow pDC GEO Mus musculus GSE62702 4,647
CEBPB pre-B-cell 48h GEO Mus musculus GSE53362 13,609
CEBPB fibroblast Thapsigargin GEO Mus musculus GSE44942 47,536
CEBPB fibroblast GEO Mus musculus GSE44942 9,581
CEBPB BMDM 30min GEO Mus musculus GSE99895 15,390
CEBPB BMDM NOD GEO Mus musculus GSE109965 77,348
CEBPB BMDM IFNg-4h GEO Mus musculus GSE84518 40,362
CEBPB hematopoietic-progenitor GEO Mus musculus GSE84328 55,115
CEBPB liver GEO Mus musculus GSE59752 63,724
CEBPB liver fasted-24h GEO Mus musculus GSE72084 68,567
CEBPB liver TCPOBOP-3h GEO Mus musculus GSE121915 55,337
CEBPB liver GEO Mus musculus GSE77670 12,387
CEBPB BMDC GEO Mus musculus GSE36099 36,515
CEBPB 3T3-L1 6h GEO Mus musculus GSE21898 29,966
CEBPB 3T3-L1 mut GEO Mus musculus GSE85100 937
CEBPB 3T3-L1 GEO Mus musculus GSE56745 15,039
CEBPB 3T3-L1 mut_Dox GEO Mus musculus GSE85100 2,791
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks