CLOCK

Information CLOCK

Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Full Name

circadian locomotor output cycles kaput

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
6
Biotypes
2
Peaks
179,377
Non-redundant peaks
101,786

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
12753
Official Gene Name
Clock
JASPAR
MGI
MGI:99698
Ensembl
ENSMUSG00000029238
UniProt
O08785
Genevisible
O08785
RefSeq
NM_007715
Aliases
5330400M04Rik; KAT13D; bHLHe8

External links
All peaks CLOCK
Download BED file
Non redundant peaks CLOCK
Download BED file
SEQUENCES CLOCK
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for CLOCK

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CLOCK liver LPS GEO Mus musculus GSE117488 28,094
CLOCK liver GEO Mus musculus GSE53828 77,209
CLOCK liver saline GEO Mus musculus GSE117488 28,968
CLOCK liver SFD GEO Mus musculus GSE117488 21,674
CLOCK liver regular-chow GEO Mus musculus GSE117488 23,269
CLOCK Beta-TC-6 GEO Mus musculus GSE70960 163
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks