CREBBP

Information CREBBP

Description

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Full Name

CREB binding protein

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
23
Biotypes
10
Peaks
519,542
Non-redundant peaks
298,119

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1387
Official Gene Name
CREBBP
JASPAR
Ensembl
ENSG00000005339
UniProt
Q92793
Genevisible
Q92793
RefSeq
NM_001079846
Aliases
CBP; KAT3A; MKHK1; RSTS; RSTS1
All peaks CREBBP
Download BED file
Non redundant peaks CREBBP
Download BED file
SEQUENCES CREBBP
Download FASTA file
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Datasets Table for CREBBP

Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
CREBBP monocyte IFNg-LPS GEO Homo sapiens GSE131294 18,178
CREBBP monocyte Resting GEO Homo sapiens GSE131294 5,244
CREBBP monocyte IFNg GEO Homo sapiens GSE131294 15,498
CREBBP monocyte LPS GEO Homo sapiens GSE131294 8,224
CREBBP PC-3 GEO Homo sapiens GSE147455 46,650
CREBBP PC-3 GDC-resist GEO Homo sapiens GSE147455 61,522
CREBBP MCF-7 ENA Homo sapiens ERP000901 68,346
CREBBP K-562 ENCODE Homo sapiens ENCSR000ATT 2,416
CREBBP LS180 125 GEO Homo sapiens GSE39277 33,063
CREBBP keratinocyte KLF3i GEO Homo sapiens GSE140991 51,216
Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
Showing 1 to 10 of 23 entries