CRTC2

Information CRTC2

Description

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250|UniProtKB:Q53ET0, ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:16308421, ECO:0000269|PubMed:29211348}.(Source UnitProtKB).

Full Name

CREB regulated transcription coactivator 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
95,930
Non-redundant peaks
58,972

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
74343
Official Gene Name
Crtc2
JASPAR
MGI
MGI:1921593
Ensembl
ENSMUSG00000027936
UniProt
Q3U182
Genevisible
Q3U182
RefSeq
NM_028881
Aliases
4632407F12Rik
All peaks CRTC2
Download BED file
Non redundant peaks CRTC2
Download BED file
SEQUENCES CRTC2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for CRTC2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CRTC2 3T3-L1 GEO Mus musculus GSE82282 45,836
CRTC2 3T3-L1 P6 GEO Mus musculus GSE82282 50,094
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks