CRTC2
Information CRTC2
- Description
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250|UniProtKB:Q53ET0, ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:16308421, ECO:0000269|PubMed:29211348}.(Source UnitProtKB).
- Full Name
CREB regulated transcription coactivator 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 95,930
- Non-redundant peaks
- 58,972
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 74343
- Official Gene Name
- Crtc2
- JASPAR
- MGI
- MGI:1921593
- Ensembl
- ENSMUSG00000027936
- UniProt
- Q3U182
- Genevisible
- Q3U182
- RefSeq
- NM_028881
- Aliases
- 4632407F12Rik
Datasets Table for CRTC2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CRTC2 | 3T3-L1 | GEO | Mus musculus | GSE82282 | 45,836 | |||
| CRTC2 | 3T3-L1 | P6 | GEO | Mus musculus | GSE82282 | 50,094 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |