CTCF

Information CTCF

Description

Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (By similarity). {ECO:0000250|UniProtKB:P49711, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:15669143, ECO:0000269|PubMed:16614224, ECO:0000269|PubMed:16951251, ECO:0000269|PubMed:17329968, ECO:0000269|PubMed:17952071, ECO:0000269|PubMed:18614575}.(Source UnitProtKB).

Full Name

CCCTC-binding factor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
386
Biotypes
91
Peaks
16,386,074
Non-redundant peaks
781,945

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
13018
Official Gene Name
Ctcf
JASPAR
MGI
MGI:109447
Ensembl
ENSMUSG00000005698
UniProt
Q61164
Genevisible
Q61164
RefSeq
Aliases
AW108038
All peaks CTCF
Download BED file
Non redundant peaks CTCF
Download BED file
SEQUENCES CTCF
Download FASTA file
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Datasets Table for CTCF

Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
CTCF spleen plasmablast GEO Mus musculus GSE44637 41,023
CTCF spleen GEO Mus musculus GSE43594 23,547
CTCF spleen stimulated GEO Mus musculus GSE43594 12,514
CTCF spleen biotag_mZF11 GEO Mus musculus GSE33819 73,084
CTCF fibroblast NIH3T3_M GEO Mus musculus GSE131356 4,716
CTCF fibroblast NIH3T3_I GEO Mus musculus GSE131356 58,723
CTCF fibroblast Xist-del GEO Mus musculus GSE67516 27,887
CTCF CH12-LX ENCODE Mus musculus ENCSR000DIU 28,452
CTCF CH12-LX ENCODE Mus musculus ENCSR000ERM 54,671
CTCF small-intestine ENCODE Mus musculus ENCSR000CED 41,671
Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
Showing 1 to 10 of 386 entries