CTNNB1

Information CTNNB1

Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Full Name

catenin beta 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
4
Peaks
50,998
Non-redundant peaks
44,762

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
1499
Official Gene Name
CTNNB1
JASPAR
Ensembl
ENSG00000168036
UniProt
P35222
Genevisible
P35222
RefSeq
NM_001098209
Aliases
CTNNB; EVR7; MRD19; NEDSDV; armadillo
All peaks CTNNB1
Download BED file
Non redundant peaks CTNNB1
Download BED file
SEQUENCES CTNNB1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for CTNNB1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CTNNB1 K-562 Wnt GEO Homo sapiens GSE117944 134
CTNNB1 LS180 GEO Homo sapiens GSE31939 9,793
CTNNB1 LS180 125 GEO Homo sapiens GSE31939 9,534
CTNNB1 hESC activinA_15h GEO Homo sapiens GSE99202 600
CTNNB1 hESC YAP-_activinA_15h GEO Homo sapiens GSE99202 1,060
CTNNB1 hiPSC TT-neg_D2 GEO Homo sapiens GSE132532 635
CTNNB1 hiPSC D2 GEO Homo sapiens GSE132532 29,242
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks