CTNNB1
Information CTNNB1
- Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
- Full Name
catenin beta 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 7
- Biotypes
- 4
- Peaks
- 50,998
- Non-redundant peaks
- 44,762
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 1499
- Official Gene Name
- CTNNB1
- JASPAR
- Ensembl
- ENSG00000168036
- UniProt
- P35222
- Genevisible
- P35222
- RefSeq
- NM_001098209
- Aliases
- CTNNB; EVR7; MRD19; NEDSDV; armadillo
Datasets Table for CTNNB1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CTNNB1 | K-562 | Wnt | GEO | Homo sapiens | GSE117944 | 134 | ||
| CTNNB1 | LS180 | GEO | Homo sapiens | GSE31939 | 9,793 | |||
| CTNNB1 | LS180 | 125 | GEO | Homo sapiens | GSE31939 | 9,534 | ||
| CTNNB1 | hESC | activinA_15h | GEO | Homo sapiens | GSE99202 | 600 | ||
| CTNNB1 | hESC | YAP-_activinA_15h | GEO | Homo sapiens | GSE99202 | 1,060 | ||
| CTNNB1 | hiPSC | TT-neg_D2 | GEO | Homo sapiens | GSE132532 | 635 | ||
| CTNNB1 | hiPSC | D2 | GEO | Homo sapiens | GSE132532 | 29,242 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |