Cdk12

The gene Cyclin-dependent kinase 12 is referred to in FlyBase by the symbol DmelCdk12 (CG7597, FBgn0037093). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 3L:21516306..21522684. Its molecular function is described by: cyclin binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity. It is involved in the biological process described with: phosphorylation of RNA polymerase II C-terminal domain; transcription by RNA polymerase II; protein phosphorylation; positive regulation of transcription elongation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter. 12 alleles are reported. The phenotypes of these alleles manifest in: larval neuroblast; ganglion mother cell. The phenotypic classes of alleles include: viable; phenotype; increased mortality during development; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Cyclin-dependent kinase 12

Source FlyBase

Drosophila melanogaster [tax_id: 7227]

dm6