DDIT3

Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15601821, PubMed:19752026). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15601821, PubMed:19752026). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (PubMed:1547942). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (PubMed:1547942). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:12706815, PubMed:15775988, PubMed:21159964, PubMed:14684614, PubMed:19919955). Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (PubMed:22242125, PubMed:23624402). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (PubMed:16670335). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (PubMed:22265908). {ECO:0000250|UniProtKB:P35638, ECO:0000269|PubMed:12706815, ECO:0000269|PubMed:14684614, ECO:0000269|PubMed:1547942, ECO:0000269|PubMed:15601821, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16670335, ECO:0000269|PubMed:19752026, ECO:0000269|PubMed:19919955, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22242125, ECO:0000269|PubMed:22265908, ECO:0000269|PubMed:23624402}.(Source UnitProtKB).

DNA-damage inducible transcript 3

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10