DGCR8

Information DGCR8

Description

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis (PubMed:17259983). Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal (PubMed:17259983). {ECO:0000250|UniProtKB:Q8WYQ5, ECO:0000269|PubMed:17259983}.(Source UnitProtKB).

Full Name

DGCR8, microprocessor complex subunit

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
4
Biotypes
1
Peaks
14,602
Non-redundant peaks
13,418

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
94223
Official Gene Name
Dgcr8
JASPAR
MGI
MGI:2151114
Ensembl
ENSMUSG00000022718
UniProt
Q9EQM6
Genevisible
Q9EQM6
RefSeq
NM_033324
Aliases
D16H22S1742E; D16H22S788E; D16Wis2; DiGeorge syndrome critical region gene 8; Gy1; N41; Vo59c07
All peaks DGCR8
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Non redundant peaks DGCR8
Download BED file
SEQUENCES DGCR8
Download FASTA file
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Datasets Table for DGCR8

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
DGCR8 mESC 37 GEO Mus musculus GSE92257 9,646
DGCR8 mESC DSG GEO Mus musculus GSE92257 4,108
DGCR8 mESC HS GEO Mus musculus GSE92257 734
DGCR8 mESC WT GEO Mus musculus GSE92257 114
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks