DMRT1
Information DMRT1
- Description
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. {ECO:0000269|PubMed:11040213, ECO:0000269|PubMed:17540358, ECO:0000269|PubMed:20007774, ECO:0000269|PubMed:20616082, ECO:0000269|PubMed:20951351, ECO:0000269|PubMed:21621532, ECO:0000269|PubMed:21775990}.(Source UnitProtKB).
- Full Name
doublesex and mab-3 related transcription factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 47,594
- Non-redundant peaks
- 47,594
TF Classification
- Familly
- DM-type intertwined zinc finger factors
- Sub Familly
- DMRT factors
Source JASPAR
External IDs
- NCBI Gene
- 50796
- Official Gene Name
- Dmrt1
- JASPAR
- MA1603.1
- MGI
- MGI:1354733
- Ensembl
- ENSMUSG00000024837
- UniProt
- Q9QZ59
- Genevisible
- Q9QZ59
- RefSeq
- NM_015826
- Aliases