DNMT3B
Information DNMT3B
- Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
- Full Name
DNA methyltransferase 3 beta
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 2
- Peaks
- 146,149
- Non-redundant peaks
- 114,551
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 1789
- Official Gene Name
- DNMT3B
- JASPAR
- Ensembl
- ENSG00000088305
- UniProt
- Q9UBC3
- Genevisible
- Q9UBC3
- RefSeq
- NM_001207055
- Aliases
- ICF; ICF1; M.HsaIIIB
Datasets Table for DNMT3B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| DNMT3B | Hep-G2 | ENCODE | Homo sapiens | ENCSR283OLA | 18,910 | |||
| DNMT3B | Hep-G2 | ENCODE | Homo sapiens | ENCSR156CWW | 9,509 | |||
| DNMT3B | HUES-8 | TripleKO-TET1-2-3 | GEO | Homo sapiens | GSE99346 | 65,007 | ||
| DNMT3B | HUES-8 | GEO | Homo sapiens | GSE99346 | 52,723 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |