DRAP1

Information DRAP1

Description

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

Full Name

DR1 associated protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
80,000
Non-redundant peaks
74,882

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
10589
Official Gene Name
DRAP1
JASPAR
Ensembl
ENSG00000175550
UniProt
Q14919
Genevisible
Q14919
RefSeq
NM_006442
Aliases
NC2-alpha
All peaks DRAP1
Download BED file
Non redundant peaks DRAP1
Download BED file
SEQUENCES DRAP1
Download FASTA file
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Datasets Table for DRAP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
DRAP1 GM12878 GEO Homo sapiens GSE97661 10,637
DRAP1 Hep-G2 ENCODE Homo sapiens ENCSR765MKZ 69,363
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks