DROSHA
Information DROSHA
- Description
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26255770). Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000250|UniProtKB:Q9NRR4, ECO:0000269|PubMed:26255770}.(Source UnitProtKB).
- Full Name
drosha, ribonuclease type III
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 595
- Non-redundant peaks
- 595
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 14000
- Official Gene Name
- Drosha
- JASPAR
- MGI
- MGI:1261425
- Ensembl
- ENSMUSG00000022191
- UniProt
- Q5HZJ0
- Genevisible
- Q5HZJ0
- RefSeq
- NM_026799
- Aliases
- 1110013A17Rik; AI874853; Etohi2; Rn3; Rnasen