DROSHA

Information DROSHA

Description

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26255770). Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000250|UniProtKB:Q9NRR4, ECO:0000269|PubMed:26255770}.(Source UnitProtKB).

Full Name

drosha, ribonuclease type III

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
595
Non-redundant peaks
595

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14000
Official Gene Name
Drosha
JASPAR
MGI
MGI:1261425
Ensembl
ENSMUSG00000022191
UniProt
Q5HZJ0
Genevisible
Q5HZJ0
RefSeq
NM_026799
Aliases
1110013A17Rik; AI874853; Etohi2; Rn3; Rnasen
All peaks DROSHA
Download BED file
Non redundant peaks DROSHA
Download BED file
SEQUENCES DROSHA
Download FASTA file
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Datasets Table for DROSHA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
DROSHA mESC DSG GEO Mus musculus GSE92257 595
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks