DUX4
Information DUX4
- Description
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- Full Name
double homeobox 4
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 84,722
- Non-redundant peaks
- 77,117
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Homeo domain factors
- Familly
- Paired-related HD factors
- Sub Familly
- DUX
Source TFClass
External IDs
- NCBI Gene
- 100288687
- Official Gene Name
- DUX4
- JASPAR
- MA0468
- Ensembl
- ENSG00000283949
- UniProt
- Q9UBX2
- Genevisible
- Q9UBX2
- RefSeq
- NM_001293798
- Aliases
Datasets Table for DUX4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| DUX4 | HEK293 | GEO | Homo sapiens | GSE75791 | 9,068 | |||
| DUX4 | WA01 | GEO | Homo sapiens | GSE94322 | 75,654 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |