E2F1
Information E2F1
- Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:11672531, PubMed:20176812). Positively regulates transcription of RRP1B (By similarity). {ECO:0000250|UniProtKB:Q01094, ECO:0000269|PubMed:11672531, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:9674698}.(Source UnitProtKB).
- Full Name
E2F transcription factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 3
- Peaks
- 28,607
- Non-redundant peaks
- 18,929
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 13555
- Official Gene Name
- E2f1
- JASPAR
- MGI
- MGI:101941
- Ensembl
- ENSMUSG00000027490
- UniProt
- Q61501
- Genevisible
- Q61501
- RefSeq
- NM_007891
- Aliases
- E2F-1; Tg(Wnt1-cre)2Sor; mKIAA4009
Datasets Table for E2F1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| E2F1 | MEF | KO | GEO | Mus musculus | GSE71376 | 1,605 | ||
| E2F1 | MEF | GEO | Mus musculus | GSE71376 | 1,979 | |||
| E2F1 | mESC | 2i | GEO | Mus musculus | GSE99847 | 9,171 | ||
| E2F1 | mESC | GEO | Mus musculus | GSE99847 | 8,028 | |||
| E2F1 | hepatocyte | GEO | Mus musculus | GSE74006 | 7,824 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |