E2F4
Information E2F4
- Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q16254, ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:17383628}.(Source UnitProtKB).
- Full Name
E2F transcription factor 4
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 5
- Peaks
- 28,626
- Non-redundant peaks
- 19,427
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 104394
- Official Gene Name
- E2f4
- JASPAR
- MGI
- MGI:103012
- Ensembl
- ENSMUSG00000014859
- UniProt
- Q8R0K9
- Genevisible
- Q8R0K9
- RefSeq
- NM_148952
- Aliases
- 2010111M04Rik
Datasets Table for E2F4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| E2F4 | CH12-LX | ENCODE | Mus musculus | ENCSR000ERU | 1,302 | |||
| E2F4 | MEL | ENCODE | Mus musculus | ENCSR000ETY | 1,009 | |||
| E2F4 | liver | GEO | Mus musculus | GSE76927 | 2,008 | |||
| E2F4 | liver | KO | GEO | Mus musculus | GSE76927 | 776 | ||
| E2F4 | myocyte | ENCODE | Mus musculus | ENCSR000AII | 16,789 | |||
| E2F4 | 3T3 | GEO | Mus musculus | GSE17067 | 6,742 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |