EGR2
Information EGR2
- Description
Sequence-specific DNA-binding transcription factor (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952, PubMed:8093858). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (PubMed:11823429). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (PubMed:1969796, PubMed:8093858, PubMed:17938205). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (PubMed:11823429, PubMed:1674431). Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain (PubMed:11823429, PubMed:8093858). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (PubMed:7935840, PubMed:10068633). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (PubMed:11509834). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (PubMed:16054051). {ECO:0000269|PubMed:10068633, ECO:0000269|PubMed:11509834, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16054051, ECO:0000269|PubMed:1674431, ECO:0000269|PubMed:17938205, ECO:0000269|PubMed:1969796, ECO:0000269|PubMed:31852952, ECO:0000269|PubMed:7935840, ECO:0000269|PubMed:8093858}.; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. {ECO:0000250|UniProtKB:P11161}.(Source UnitProtKB).
- Full Name
early growth response 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 9
- Biotypes
- 5
- Peaks
- 23,688
- Non-redundant peaks
- 15,780
TF Classification
- Familly
- C2H2 zinc finger factors
- Sub Familly
- Three-zinc finger Kruppel-related factors
Source JASPAR
Datasets Table for EGR2
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
EGR2 | BMDC | GEO | Mus musculus | GSE36099 | 1,599 | |||
EGR2 | BMDC | 30min | GEO | Mus musculus | GSE36099 | 4,566 | ||
EGR2 | BMDC | 1h | GEO | Mus musculus | GSE36099 | 2,627 | ||
EGR2 | BMDC | 2h | GEO | Mus musculus | GSE36099 | 1,390 | ||
EGR2 | NKT | GEO | Mus musculus | GSE34254 | 632 | |||
EGR2 | CD4-pos | GEO | Mus musculus | GSE46241 | 10,127 | |||
EGR2 | spleen | 16h | GEO | Mus musculus | GSE49366 | 544 | ||
EGR2 | spleen | 4h | GEO | Mus musculus | GSE49366 | 763 | ||
EGR2 | thymocyte | GEO | Mus musculus | GSE34254 | 1,440 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |