EGR2

Information EGR2

Description

Sequence-specific DNA-binding transcription factor (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (PubMed:1969796, PubMed:1674431, PubMed:11823429, PubMed:31852952, PubMed:8093858). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (PubMed:11823429). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (PubMed:1969796, PubMed:8093858, PubMed:17938205). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (PubMed:11823429, PubMed:1674431). Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain (PubMed:11823429, PubMed:8093858). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (PubMed:7935840, PubMed:10068633). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (PubMed:11509834). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (PubMed:16054051). {ECO:0000269|PubMed:10068633, ECO:0000269|PubMed:11509834, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16054051, ECO:0000269|PubMed:1674431, ECO:0000269|PubMed:17938205, ECO:0000269|PubMed:1969796, ECO:0000269|PubMed:31852952, ECO:0000269|PubMed:7935840, ECO:0000269|PubMed:8093858}.; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. {ECO:0000250|UniProtKB:P11161}.(Source UnitProtKB).

Full Name

early growth response 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
9
Biotypes
5
Peaks
23,688
Non-redundant peaks
15,780

TF Classification

Familly
C2H2 zinc finger factors
Sub Familly
Three-zinc finger Kruppel-related factors

Source JASPAR

External IDs

NCBI Gene
13654
Official Gene Name
Egr2
JASPAR
MA0472.1
MGI
MGI:95296
Ensembl
ENSMUSG00000037868
UniProt
P08152
Genevisible
P08152
RefSeq
NM_010118
Aliases
Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6
All peaks EGR2
Download BED file
Non redundant peaks EGR2
Download BED file
SEQUENCES EGR2
Download FASTA file
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Datasets Table for EGR2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EGR2 BMDC GEO Mus musculus GSE36099 1,599
EGR2 BMDC 30min GEO Mus musculus GSE36099 4,566
EGR2 BMDC 1h GEO Mus musculus GSE36099 2,627
EGR2 BMDC 2h GEO Mus musculus GSE36099 1,390
EGR2 NKT GEO Mus musculus GSE34254 632
EGR2 CD4-pos GEO Mus musculus GSE46241 10,127
EGR2 spleen 16h GEO Mus musculus GSE49366 544
EGR2 spleen 4h GEO Mus musculus GSE49366 763
EGR2 thymocyte GEO Mus musculus GSE34254 1,440
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks