EHMT2

Information EHMT2

Description

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000269|PubMed:12130538, ECO:0000269|PubMed:15774718, ECO:0000269|PubMed:18818694, ECO:0000269|PubMed:22387026}.(Source UnitProtKB).

Full Name

euchromatic histone lysine N-methyltransferase 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
487
Non-redundant peaks
430

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
110147
Official Gene Name
Ehmt2
JASPAR
MGI
MGI:2148922
Ensembl
ENSMUSG00000013787
UniProt
Q9Z148
Genevisible
Q9Z148
RefSeq
NM_147151
Aliases
Bat8; D17Ertd710e; G9a; KMT1C; NG36
All peaks EHMT2
Download BED file
Non redundant peaks EHMT2
Download BED file
SEQUENCES EHMT2
Download FASTA file
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Datasets Table for EHMT2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EHMT2 mESC Tt2-KO GEO Mus musculus GSE46536 250
EHMT2 mESC GEO Mus musculus GSE46536 237
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks