Information EP300


Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (By similarity). Acetylates all four core histones in nucleosomes (By similarity). Histone acetylation gives an epigenetic tag for transcriptional activation (By similarity). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein (PubMed:18486321, PubMed:24216764). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity). Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (By similarity). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:28883095, PubMed:28576496). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (By similarity). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (By similarity). Acetylates HDAC1 leading to its inactivation and modulation of transcription (By similarity). Acetylates 'Lys-247' of EGR2 (PubMed:28576496). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (By similarity). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium (By similarity). Promotes cardiac myocyte enlargement (By similarity). Can also mediate transcriptional repression (By similarity). Acetylates FOXO1 and enhances its transcriptional activity (By similarity). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (By similarity). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (By similarity). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (PubMed:25200183). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:27105113). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (By similarity). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:27105113). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (By similarity). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes. Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (By similarity). Acetylates RXRA and RXRG (By similarity). {ECO:0000250|UniProtKB:Q09472, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18486321, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:24216764, ECO:0000269|PubMed:25200183, ECO:0000269|PubMed:27105113, ECO:0000269|PubMed:28576496, ECO:0000269|PubMed:28883095, ECO:0000269|PubMed:9512516, ECO:0000305|PubMed:20955178}.(Source UnitProtKB).

Full Name

E1A binding protein p300

Source UniprotKB


Mus musculus [tax_id: 10090]



ReMap Statistics

Non-redundant peaks

TF Classification

Sub Familly


External IDs

Official Gene Name
KAT3B; p300
All peaks EP300
Download BED file
Non redundant peaks EP300
Download BED file
Download FASTA file
Got to catalogue

Datasets Table for EP300

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EP300 spleen IL2-12 GEO Mus musculus GSE77695 22,715
EP300 CH12-LX ENCODE Mus musculus ENCSR000ERI 16,668
EP300 Th1 DN GEO Mus musculus GSE60353 25,116
EP300 MEL ENCODE Mus musculus ENCSR000ETP 34,041
EP300 liver mut GEO Mus musculus GSE26729 146
EP300 liver ENCODE Mus musculus ENCSR765RPR 19,257
EP300 HPC-7 shSCR GEO Mus musculus GSE76053 2,085
EP300 pre-iPSC GEO Mus musculus GSE90893 30,736
EP300 cortex GEO Mus musculus GSE42881 27,308
EP300 pre-B-cell 3h GEO Mus musculus GSE53362 29,362
EP300 macrophage alveaolar GEO Mus musculus GSE75722 17,573
EP300 macrophage MAFB GEO Mus musculus GSE75722 22,712
EP300 3T3 GEO Mus musculus GSE17067 227
EP300 Th17 Stat3-fl-fl GEO Mus musculus GSE40918 10,959
EP300 Th17 Irf4-pos-pos GEO Mus musculus GSE40918 29,813
EP300 Th17 Batf-neg-neg GEO Mus musculus GSE40918 36,690
EP300 Th17 Stat3-pos-pos GEO Mus musculus GSE40918 29,414
EP300 Th17 Rorc-WT GEO Mus musculus GSE40918 49,536
EP300 Th17 Irf4-neg-neg GEO Mus musculus GSE40918 24,848
EP300 Th17 Rorc-KO GEO Mus musculus GSE40918 37,535
EP300 Th17 Trim28-KO GEO Mus musculus GSE98427 9,997
EP300 whole-embryo GEO Mus musculus GSE88789 23,947
EP300 C2C12 myoblast GEO Mus musculus GSE37525 1,488
EP300 kidney GEO Mus musculus GSE29218 4,927
EP300 preadipocyte 4h GEO Mus musculus GSE95533 38,502
EP300 chondrocyte rib GEO Mus musculus GSE69109 23,505
EP300 dendritic-cell GEO Mus musculus GSE66899 1,760
EP300 B-cell activated GEO Mus musculus GSE82144 22,877
EP300 B-cell resting GEO Mus musculus GSE82144 26,059
EP300 endothelial-embryo VecadCre GEO Mus musculus GSE88789 1,268
EP300 brain GEO Mus musculus GSE60409 504
EP300 mESC CKO_Tam GEO Mus musculus GSE58407 205
EP300 mESC 10k GEO Mus musculus GSE109757 359
EP300 mESC GEO Mus musculus GSE56098 38,549
EP300 mESC GEO Mus musculus GSE29218 40,509
EP300 mESC min-RNase GEO Mus musculus GSE66830 7,003
EP300 mESC AntNPC GEO Mus musculus GSE89209 880
EP300 mESC plus-RNase GEO Mus musculus GSE66830 13,198
EP300 mESC dR-cell GEO Mus musculus GSE58407 7,650
EP300 mESC GEO Mus musculus GSE89209 30,782
EP300 mESC GEO Mus musculus GSE24164 28,104
EP300 mESC GEO Mus musculus GSE97701 1,366
EP300 ES-Bruce4 ENCODE Mus musculus ENCSR000CCD 42,497
EP300 lung GEO Mus musculus GSE29218 8,943
EP300 lung ENCODE Mus musculus ENCSR527DME 22,267
EP300 CD8-pos GEO Mus musculus GSE77857 15,823
EP300 heart EIIaCre GEO Mus musculus GSE88789 66,222
EP300 motor-neuron d5 GEO Mus musculus GSE79561 13,413
EP300 EpiLC CKO_Tam GEO Mus musculus GSE58407 403
EP300 HL-1 GEO Mus musculus GSE21529 1,057
EP300 Th2 STAT6-KO_ctrl GEO Mus musculus GSE40463 68,702
EP300 AtT-20 GEO Mus musculus GSE64483 26,530
EP300 AtT-20 GEO Mus musculus GSE87180 58,361
EP300 AtT-20 Pax7 GEO Mus musculus GSE87180 34,930
EP300 TSC GEO Mus musculus GSE110950 11,960
EP300 Th0 GEO Mus musculus GSE40918 7,010
EP300 BMDM IL4-6h GEO Mus musculus GSE107456 39,292
EP300 BMDM GEO Mus musculus GSE106701 76,274
EP300 BMDM IL4-24h GEO Mus musculus GSE107456 24,601
EP300 BMDM GEO Mus musculus GSE107456 26,338
EP300 BMDM IL4-1h GEO Mus musculus GSE107456 20,990
EP300 BMDM GEO Mus musculus GSE75722 4,965
EP300 endothelial-embryo GEO Mus musculus GSE88789 3,749
EP300 Th1 GEO Mus musculus GSE60353 22,040
EP300 brown-preadipocyte KO GEO Mus musculus GSE74189 62,848
EP300 heart GEO Mus musculus GSE29218 45,464
EP300 heart ENCODE Mus musculus ENCSR777VNA 13,637
EP300 heart ENCODE Mus musculus ENCSR000CCA 58,806
EP300 heart GEO Mus musculus GSE88789 33,497
EP300 lung GEO Mus musculus GSE88789 17,187
EP300 lung VecadCre GEO Mus musculus GSE88789 1,284
EP300 preadipocyte D0 GEO Mus musculus GSE95533 13,956
EP300 pre-B-cell 0h GEO Mus musculus GSE53362 21,825
EP300 pre-B-cell 24h GEO Mus musculus GSE53362 19,775
EP300 pre-B-cell 12h GEO Mus musculus GSE53362 25,439
EP300 spleen GEO Mus musculus GSE77695 25,294
EP300 Th17 GEO Mus musculus GSE98427 7,640
EP300 Th17 GEO Mus musculus GSE40918 32,846
EP300 Th17 Batf-pos-pos GEO Mus musculus GSE40918 52,868
EP300 MEL ENCODE Mus musculus ENCSR000ETV 23,204
EP300 TSC differentiated GEO Mus musculus GSE110950 55,709
EP300 macrophage MAF-DKO GEO Mus musculus GSE75722 14,965
EP300 liver ENCODE Mus musculus ENCSR982LJQ 15,688
EP300 liver GEO Mus musculus GSE29218 2,320
EP300 mESC GEO Mus musculus GSE140546 40,448
EP300 mESC KO GEO Mus musculus GSE140546 37,748
EP300 mESC 2i GEO Mus musculus GSE89209 7,069
EP300 mESC 2k GEO Mus musculus GSE129333 20,028
EP300 mESC GEO Mus musculus GSE22341 4,468
EP300 mESC CKO_EtOH GEO Mus musculus GSE58407 413
EP300 mESC GEO Mus musculus GSE90893 18,069
EP300 mESC GEO Mus musculus GSE110950 8,883
EP300 mESC 100 GEO Mus musculus GSE129333 12,001
EP300 HPC-7 shMed12 GEO Mus musculus GSE76053 448
EP300 HPC-7 GEO Mus musculus GSE76053 356
EP300 3T3-L1 rosi GEO Mus musculus GSE56745 24,933
EP300 3T3-L1 GEO Mus musculus GSE56745 27,390
EP300 C2C12 myotube GEO Mus musculus GSE37525 5,978
EP300 forebrain GEO Mus musculus GSE42881 680
EP300 forebrain GEO Mus musculus GSE88789 7,570
EP300 stomach ENCODE Mus musculus ENCSR450KVW 5,514
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks