EP400
Information EP400
- Description
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42. {ECO:0000250}.(Source UnitProtKB).
- Full Name
E1A binding protein p400
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 1
- Peaks
- 23,612
- Non-redundant peaks
- 19,508
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 75560
- Official Gene Name
- Ep400
- JASPAR
- MGI
- MGI:1276124
- Ensembl
- ENSMUSG00000029505
- UniProt
- Q8CHI8
- Genevisible
- Q8CHI8
- RefSeq
- NM_173066
- Aliases
- 1700020J09Rik; mDomino; p400
Datasets Table for EP400
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| EP400 | mESC | DRB | GEO | Mus musculus | GSE67580 | 9,550 | ||
| EP400 | mESC | RH | GEO | Mus musculus | GSE67580 | 334 | ||
| EP400 | mESC | GEO | Mus musculus | GSE67580 | 1,501 | |||
| EP400 | mESC | TRI | GEO | Mus musculus | GSE67580 | 12,227 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |