EPOP
Information EPOP
- Description
Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex (PubMed:27863225, PubMed:27863226). Interaction with USP7 promotes deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766). {ECO:0000269|PubMed:23180766, ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}.(Source UnitProtKB).
- Full Name
elongin BC and polycomb repressive complex 2 associated protein
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 7
- Biotypes
- 1
- Peaks
- 89,288
- Non-redundant peaks
- 47,135
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 103551
- Official Gene Name
- Epop
- JASPAR
- MGI
- MGI:2143991
- Ensembl
- ENSMUSG00000043439
- UniProt
- Q7TNS8
- Genevisible
- Q7TNS8
- RefSeq
- NM_175332
- Aliases
- E13; E130012A19Rik
Datasets Table for EPOP
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| EPOP | mESC | GEO | Mus musculus | GSE79606 | 9,326 | |||
| EPOP | mESC | GEO | Mus musculus | GSE132752 | 23,475 | |||
| EPOP | mESC | PARETA | GEO | Mus musculus | GSE134053 | 12,454 | ||
| EPOP | mESC | PAR-72 | GEO | Mus musculus | GSE134053 | 4,103 | ||
| EPOP | mESC | I53S72 | GEO | Mus musculus | GSE134053 | 4,921 | ||
| EPOP | mESC | TAM | GEO | Mus musculus | GSE132752 | 22,681 | ||
| EPOP | mESC | WT72 | GEO | Mus musculus | GSE134053 | 12,328 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |