ESR1

Information ESR1

Description

This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Full Name

estrogen receptor 1 (alpha)

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
28
Biotypes
7
Peaks
703,143
Non-redundant peaks
299,361

TF Classification

Familly
Nuclear receptors with C4 zinc fingers
Sub Familly
Steroid hormone receptors (NR3)

Source JASPAR

External IDs

NCBI Gene
13982
Official Gene Name
Esr1
JASPAR
MA0112.1
MGI
MGI:1352467
Ensembl
ENSMUSG00000019768
UniProt
P19785
Genevisible
P19785
RefSeq
NM_007956
Aliases
ER; ER-alpha; ER[a]; ERa; ERalpha; ESR; Estr; Estra; Nr3a1

External links
All peaks ESR1
Download BED file
Non redundant peaks ESR1
Download BED file
SEQUENCES ESR1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for ESR1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ESR1 liver GEO Mus musculus GSE49993 9,931
ESR1 liver GEO Mus musculus GSE70346 1,525
ESR1 liver placebo GEO Mus musculus GSE70346 101
ESR1 mammary-epithelium HA-hERa GEO Mus musculus GSE127859 43,846
ESR1 mammary-epithelium HA-mERa GEO Mus musculus GSE127859 36,077
ESR1 uterus Veh-21d GEO Mus musculus GSE125972 70,204
ESR1 uterus 12h GEO Mus musculus GSE125972 22,239
ESR1 uterus 8h GEO Mus musculus GSE125972 58,221
ESR1 uterus veh GEO Mus musculus GSE137196 54,323
ESR1 uterus AF-2-mut_veh GEO Mus musculus GSE137196 70,428
ESR1 mammary-gland GEO Mus musculus GSE77586 75,448
ESR1 ovary GEO Mus musculus GSE62545 9,536
ESR1 uterus GEO Mus musculus GSE94737 36,668
ESR1 uterus 6h GEO Mus musculus GSE125972 40,804
ESR1 uterus E2-1h GEO Mus musculus GSE94737 58,014
ESR1 uterus GEO Mus musculus GSE49993 36,055
ESR1 mammary-gland GEO Mus musculus GSE43415 735
ESR1 mammary-gland GEO Mus musculus GSE129847 17,642
ESR1 aorta GEO Mus musculus GSE52351 1,405
ESR1 liver GEO Mus musculus GSE52351 59,941
ESR1 DBD mammary-cell DBD-mut_Dex-E2 GEO Mus musculus GSE46123 53,778
ESR1 mammary-cell Afos_Dex-E2 GEO Mus musculus GSE46123 5,411
ESR1 mammary-cell GEO Mus musculus GSE46123 29,236
ESR1 mammary-cell Afos_E2 GEO Mus musculus GSE46123 20,173
ESR1 mammary-cell Dex-E2 GEO Mus musculus GSE46123 29,400
ESR1 mammary-cell E2 GEO Mus musculus GSE46123 36,277
ESR1 mammary-cell DBD-mut_E2 GEO Mus musculus GSE46123 38,241
ESR1 mammary-cell Dex GEO Mus musculus GSE46123 73,251
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks