ESR2

Information ESR2

Description

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Full Name

estrogen receptor 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
40,692
Non-redundant peaks
31,725

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
Nuclear receptors with C4 zinc fingers
Familly
Steroid hormone receptors (NR3)
Sub Familly
ER-like receptors (NR3A&B)

Source TFClass

External IDs

NCBI Gene
2100
Official Gene Name
ESR2
JASPAR
MA0258
Ensembl
ENSG00000140009
UniProt
Q92731
Genevisible
Q92731
RefSeq
NM_001040275
Aliases
ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8
All peaks ESR2
Download BED file
Non redundant peaks ESR2
Download BED file
SEQUENCES ESR2
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for ESR2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ESR2 MDA-MB-231 estradiol GEO Homo sapiens GSE108979 30,188
ESR2 MDA-MB-231 LY500307 GEO Homo sapiens GSE108979 8,703
ESR2 MCF-7 C412_E2 GEO Homo sapiens GSE48096 1,801
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks