ESRRB

Information ESRRB

Description

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:27601327, PubMed:23169531, PubMed:23508100, PubMed:26206133, PubMed:20534447, PubMed:18662995, PubMed:18957414, PubMed:27723719, PubMed:23019124). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414, PubMed:26206133, PubMed:20534447, PubMed:23040478, PubMed:23040477, PubMed:23019124, PubMed:23169531). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133). Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:18662995, PubMed:23508100, PubMed:18957414). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase (PubMed:27723719). Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:23019124, PubMed:23169531, PubMed:18662995, PubMed:26206133). This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531). Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:9285590, PubMed:17765677). {ECO:0000250|UniProtKB:O95718, ECO:0000269|PubMed:17765677, ECO:0000269|PubMed:18662995, ECO:0000269|PubMed:18957414, ECO:0000269|PubMed:20534447, ECO:0000269|PubMed:23019124, ECO:0000269|PubMed:23040477, ECO:0000269|PubMed:23040478, ECO:0000269|PubMed:23169531, ECO:0000269|PubMed:23508100, ECO:0000269|PubMed:26206133, ECO:0000269|PubMed:27601327, ECO:0000269|PubMed:27723719, ECO:0000269|PubMed:9285590}.(Source UnitProtKB).

Full Name

estrogen related receptor, beta

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
15
Biotypes
4
Peaks
333,197
Non-redundant peaks
164,406

TF Classification

Familly
Nuclear receptors with C4 zinc fingers
Sub Familly
Steroid hormone receptors (NR3)

Source JASPAR

External IDs

NCBI Gene
26380
Official Gene Name
Esrrb
JASPAR
MA0141.2
MGI
MGI:1346832
Ensembl
ENSMUSG00000021255
UniProt
Q61539
Genevisible
Q61539
RefSeq
NM_011934
Aliases
ERR2; ERRb; Err2; Errb; Estrrb; Nr3b2
All peaks ESRRB
Download BED file
Non redundant peaks ESRRB
Download BED file
SEQUENCES ESRRB
Download FASTA file
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Datasets Table for ESRRB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ESRRB MEF GEO Mus musculus GSE89155 7,929
ESRRB MEF Zic3 GEO Mus musculus GSE89155 23,354
ESRRB trophoblast-stem-cell GEO Mus musculus GSE123361 167
ESRRB mESC CRISPR GEO Mus musculus GSE92407 44,331
ESRRB mESC siEsrrb GEO Mus musculus GSE115340 4,327
ESRRB mESC Interphase_PFA GEO Mus musculus GSE122589 9,679
ESRRB mESC GEO Mus musculus GSE90893 74,401
ESRRB mESC serum GEO Mus musculus GSE92407 5,418
ESRRB mESC Mitosis_PFA GEO Mus musculus GSE122589 3,737
ESRRB mESC siCtrl GEO Mus musculus GSE115340 30,907
ESRRB mESC Dox-min GEO Mus musculus GSE118898 7,177
ESRRB TSC GEO Mus musculus GSE104695 28,783
ESRRB mESC 2i-D3 GEO Mus musculus GSE92407 8,336
ESRRB mESC Mitosis_DSGPFA GEO Mus musculus GSE122589 64,667
ESRRB mESC Dox-plus GEO Mus musculus GSE118898 19,984
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks