ESRRB
Information ESRRB
- Description
Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:27601327, PubMed:23169531, PubMed:23508100, PubMed:26206133, PubMed:20534447, PubMed:18662995, PubMed:18957414, PubMed:27723719, PubMed:23019124). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414, PubMed:26206133, PubMed:20534447, PubMed:23040478, PubMed:23040477, PubMed:23019124, PubMed:23169531). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133). Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:18662995, PubMed:23508100, PubMed:18957414). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase (PubMed:27723719). Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:23019124, PubMed:23169531, PubMed:18662995, PubMed:26206133). This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531). Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:9285590, PubMed:17765677). {ECO:0000250|UniProtKB:O95718, ECO:0000269|PubMed:17765677, ECO:0000269|PubMed:18662995, ECO:0000269|PubMed:18957414, ECO:0000269|PubMed:20534447, ECO:0000269|PubMed:23019124, ECO:0000269|PubMed:23040477, ECO:0000269|PubMed:23040478, ECO:0000269|PubMed:23169531, ECO:0000269|PubMed:23508100, ECO:0000269|PubMed:26206133, ECO:0000269|PubMed:27601327, ECO:0000269|PubMed:27723719, ECO:0000269|PubMed:9285590}.(Source UnitProtKB).
- Full Name
estrogen related receptor, beta
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 15
- Biotypes
- 4
- Peaks
- 333,197
- Non-redundant peaks
- 164,406
TF Classification
- Familly
- Nuclear receptors with C4 zinc fingers
- Sub Familly
- Steroid hormone receptors (NR3)
Source JASPAR
External IDs
- NCBI Gene
- 26380
- Official Gene Name
- Esrrb
- JASPAR
- MA0141.2
- MGI
- MGI:1346832
- Ensembl
- ENSMUSG00000021255
- UniProt
- Q61539
- Genevisible
- Q61539
- RefSeq
- NM_011934
- Aliases
- ERR2; ERRb; Err2; Errb; Estrrb; Nr3b2
Datasets Table for ESRRB
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
ESRRB | MEF | GEO | Mus musculus | GSE89155 | 7,929 | |||
ESRRB | MEF | Zic3 | GEO | Mus musculus | GSE89155 | 23,354 | ||
ESRRB | trophoblast-stem-cell | GEO | Mus musculus | GSE123361 | 167 | |||
ESRRB | mESC | CRISPR | GEO | Mus musculus | GSE92407 | 44,331 | ||
ESRRB | mESC | siEsrrb | GEO | Mus musculus | GSE115340 | 4,327 | ||
ESRRB | mESC | Interphase_PFA | GEO | Mus musculus | GSE122589 | 9,679 | ||
ESRRB | mESC | GEO | Mus musculus | GSE90893 | 74,401 | |||
ESRRB | mESC | serum | GEO | Mus musculus | GSE92407 | 5,418 | ||
ESRRB | mESC | Mitosis_PFA | GEO | Mus musculus | GSE122589 | 3,737 | ||
ESRRB | mESC | siCtrl | GEO | Mus musculus | GSE115340 | 30,907 | ||
ESRRB | mESC | Dox-min | GEO | Mus musculus | GSE118898 | 7,177 | ||
ESRRB | TSC | GEO | Mus musculus | GSE104695 | 28,783 | |||
ESRRB | mESC | 2i-D3 | GEO | Mus musculus | GSE92407 | 8,336 | ||
ESRRB | mESC | Mitosis_DSGPFA | GEO | Mus musculus | GSE122589 | 64,667 | ||
ESRRB | mESC | Dox-plus | GEO | Mus musculus | GSE118898 | 19,984 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |