EVI1

Information EVI1

Description

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Full Name

MDS1 and EVI1 complex locus

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
1
Peaks
64,291
Non-redundant peaks
43,957

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
2122
Official Gene Name
MECOM
JASPAR
Ensembl
ENSG00000085276
UniProt
Q03112
Genevisible
Q03112
RefSeq
NM_001105077
Aliases
AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; PRDM3; RUSAT2
All peaks EVI1
Download BED file
Non redundant peaks EVI1
Download BED file
SEQUENCES EVI1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for EVI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MECOM SKH1 CEBPA-ER_E2 GEO Homo sapiens GSE102697 24,980
MECOM SKH1 E2 GEO Homo sapiens GSE102697 19,392
MECOM SKH1 CEBPA-ER GEO Homo sapiens GSE102697 28,334
MECOM SKH1 GEO Homo sapiens GSE102697 15,219
MECOM SKH1 RUNX1-EVI1_KD GEO Homo sapiens GSE87283 5,660
MECOM SKH1 GEO Homo sapiens GSE87283 34,467
MECOM SKH1 10d GEO Homo sapiens GSE87283 24,164
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks