EZH2

Information EZH2

Description

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000250|UniProtKB:Q15910, ECO:0000269|PubMed:12689588, ECO:0000269|PubMed:15516932, ECO:0000269|PubMed:15520282, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:19026780}.(Source UnitProtKB).

Full Name

enhancer of zeste 2 polycomb repressive complex 2 subunit

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
70
Biotypes
20
Peaks
544,635
Non-redundant peaks
186,601

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14056
Official Gene Name
Ezh2
JASPAR
MGI
MGI:107940
Ensembl
ENSMUSG00000029687
UniProt
Q61188
Genevisible
Q61188
RefSeq
Aliases
Enx-1; Enx1h; KMT6; mKIAA4065
All peaks EZH2
Download BED file
Non redundant peaks EZH2
Download BED file
SEQUENCES EZH2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for EZH2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EZH2 EML GEO Mus musculus GSE75186 5,381
EZH2 spleen Th2 GEO Mus musculus GSE51079 10,486
EZH2 E14 GEO Mus musculus GSE49431 16,180
EZH2 Th1 GEO Mus musculus GSE51079 10,507
EZH2 MEF GEO Mus musculus GSE77993 902
EZH2 C2C12 GEO Mus musculus GSE74049 114
EZH2 C2C12 GEO Mus musculus GSE45875 8,576
EZH2 heart-apex GEO Mus musculus GSE29994 3,068
EZH2 testis d0 GEO Mus musculus GSE111146 41,102
EZH2 testis d3 GEO Mus musculus GSE111146 19,062
EZH2 mESC GEO Mus musculus GSE78899 1,389
EZH2 mESC P132S GEO Mus musculus GSE111433 5,946
EZH2 mESC GEO Mus musculus GSE111433 3,735
EZH2 mESC d7 GEO Mus musculus GSE36905 5,254
EZH2 mESC 2i GEO Mus musculus GSE23943 33,231
EZH2 mESC GEO Mus musculus GSE94300 6,010
EZH2 mESC Kdm2bKO GEO Mus musculus GSE41314 5,813
EZH2 mESC Tt2-0 GEO Mus musculus GSE46536 3,493
EZH2 mESC GEO Mus musculus GSE41314 6,975
EZH2 mESC GEO Mus musculus GSE55697 5,151
EZH2 mESC E14-serum GEO Mus musculus GSE23943 7,342
EZH2 mESC 129B6F1_SUZ12-KO GEO Mus musculus GSE103685 1,798
EZH2 mESC 2k GEO Mus musculus GSE129333 12,613
EZH2 mESC Smchd1-neg GEO Mus musculus GSE126257 629
EZH2 mESC MTF2-GT GEO Mus musculus GSE94300 1,402
EZH2 mESC F145L GEO Mus musculus GSE111433 4,289
EZH2 mESC E14-2i GEO Mus musculus GSE23943 10,384
EZH2 mESC GEO Mus musculus GSE43229 4,112
EZH2 mESC GEO Mus musculus GSE94834 7,661
EZH2 mESC KO GEO Mus musculus GSE123174 2,275
EZH2 mESC GEO Mus musculus GSE118115 7,842
EZH2 mESC ES-WT GEO Mus musculus GSE85717 11,524
EZH2 mESC GEO Mus musculus GSE85717 8,171
EZH2 mESC shGFP GEO Mus musculus GSE49178 20,128
EZH2 mESC GEO Mus musculus GSE60160 8,312
EZH2 mESC Dicer-KO GEO Mus musculus GSE60160 5,440
EZH2 mESC shDnmt3l GEO Mus musculus GSE49178 23,734
EZH2 mESC KO GEO Mus musculus GSE118115 20,255
EZH2 CD8-pos GEO Mus musculus GSE89405 11,132
EZH2 EBs STIL-KO GEO Mus musculus GSE47082 4,385
EZH2 mammary-gland GEO Mus musculus GSE70440 2,721
EZH2 motor-neuron GEO Mus musculus GSE60232 3,468
EZH2 motor-neuron delta-5-6 GEO Mus musculus GSE60232 1,973
EZH2 TSC BC GEO Mus musculus GSE118399 830
EZH2 colon GEO Mus musculus GSE84858 23,535
EZH2 mESC-E14 GEO Mus musculus GSE103180 7,084
EZH2 BMDM LPS-2h GEO Mus musculus GSE101320 12,210
EZH2 erythroid WT GEO Mus musculus GSE97869 1,002
EZH2 erythroid D839 GEO Mus musculus GSE97869 2,124
EZH2 fibroblast GEO Mus musculus GSE56981 4,748
EZH2 BMDM GEO Mus musculus GSE101320 15,302
EZH2 TSC CB GEO Mus musculus GSE118399 3,404
EZH2 MEF SS GEO Mus musculus GSE77993 3,480
EZH2 MEF GEO Mus musculus GSE36905 3,101
EZH2 NPC GEO Mus musculus GSE89929 26,119
EZH2 mESC treated GEO Mus musculus GSE55697 6,428
EZH2 mESC GEO Mus musculus GSE123174 3,549
EZH2 mESC GEO Mus musculus GSE36905 5,933
EZH2 mESC GEO Mus musculus GSE126257 1,295
EZH2 mESC serum GEO Mus musculus GSE23943 7,309
EZH2 mESC GEO Mus musculus GSE104659 561
EZH2 mESC GEO Mus musculus GSE89929 19,911
EZH2 mESC 100 GEO Mus musculus GSE129333 9,440
EZH2 mESC GEO Mus musculus GSE46536 4,551
EZH2 mESC KDM4C-KO GEO Mus musculus GSE43229 1,444
EZH2 mESC Tmx GEO Mus musculus GSE66830 752
EZH2 mESC 129B6F1 GEO Mus musculus GSE103685 460
EZH2 mESC Tt2-KO GEO Mus musculus GSE46536 3,212
EZH2 EBs GEO Mus musculus GSE47082 2,598
EZH2 C2C12 GEO Mus musculus GSE25549 288
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks