EZH2
Information EZH2
- Description
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
- Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunit
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 96
- Biotypes
- 57
- Peaks
- 1,183,876
- Non-redundant peaks
- 609,918
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 2146
- Official Gene Name
- EZH2
- JASPAR
- Ensembl
- ENSG00000106462
- UniProt
- Q15910
- Genevisible
- Q15910
- RefSeq
- NM_001203247
- Aliases
- ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2
Datasets Table for EZH2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| EZH2 | RCH-ACV | GEO | Homo sapiens | GSE135024 | 8,311 | |||
| EZH2 | DU145 | SH4 | GEO | Homo sapiens | GSE135623 | 3,056 | ||
| EZH2 | OCI-Ly7 | GEO | Homo sapiens | GSE45982 | 1,340 | |||
| EZH2 | T-REx-293 | K27WT_24h | GEO | Homo sapiens | GSE118954 | 626 | ||
| EZH2 | T-REx-293 | K27WT_6h | GEO | Homo sapiens | GSE118954 | 1,705 | ||
| EZH2 | T-REx-293 | K27WT | GEO | Homo sapiens | GSE118954 | 643 | ||
| EZH2 | T-REx-293 | K27WT_72h | GEO | Homo sapiens | GSE118954 | 881 | ||
| EZH2 | T-REx-293 | K27WT_12h | GEO | Homo sapiens | GSE118954 | 1,034 | ||
| EZH2 | Pfeiffer | GEO | Homo sapiens | GSE45982 | 8,685 | |||
| EZH2 | SU-DHL-5 | GEO | Homo sapiens | GSE45982 | 68,654 | |||
| EZH2 | ME-1 | Con | GEO | Homo sapiens | GSE128771 | 3,378 | ||
| EZH2 | ME-1 | KD | GEO | Homo sapiens | GSE128771 | 5,741 | ||
| EZH2 | OCI-Ly1 | GEO | Homo sapiens | GSE45982 | 2,942 | |||
| EZH2 | VCaP | DHAT_2H | GEO | Homo sapiens | GSE28950 | 3,364 | ||
| EZH2 | VCaP | ETOH | GEO | Homo sapiens | GSE28950 | 2,404 | ||
| EZH2 | THP-1 | GEO | Homo sapiens | GSE135024 | 72,696 | |||
| EZH2 | Karpas-422 | DMSO-D8 | GEO | Homo sapiens | GSE134136 | 2,819 | ||
| EZH2 | Karpas-422 | CPI360-D4 | GEO | Homo sapiens | GSE134136 | 7,409 | ||
| EZH2 | Karpas-422 | CPI360-D8 | GEO | Homo sapiens | GSE134136 | 9,685 | ||
| EZH2 | RL | CPI169-10d | GEO | Homo sapiens | GSE134136 | 7,304 | ||
| EZH2 | RL | GEO | Homo sapiens | GSE134136 | 285 | |||
| EZH2 | A-1847 | GEO | Homo sapiens | GSE95643 | 27,689 | |||
| EZH2 | A-1847 | CARM1-KO | GEO | Homo sapiens | GSE95643 | 64,756 | ||
| EZH2 | SU-DHL-6 | GEO | Homo sapiens | GSE45982 | 7,569 | |||
| EZH2 | SU-DHL-6 | GEO | Homo sapiens | GSE134136 | 41,132 | |||
| EZH2 | SU-DHL-6 | DMSO | GEO | Homo sapiens | GSE134136 | 11,526 | ||
| EZH2 | LNCaP-abl | GEO | Homo sapiens | GSE39459 | 49,540 | |||
| EZH2 | Jurkat | KO | GEO | Homo sapiens | GSE147198 | 9,834 | ||
| EZH2 | Jurkat | GEO | Homo sapiens | GSE147198 | 3,191 | |||
| EZH2 | SF8628 | GEO | Homo sapiens | GSE94834 | 19,137 | |||
| EZH2 | K-562 | GEO | Homo sapiens | GSE97661 | 1,923 | |||
| EZH2 | WSU-DLCL2 | GEO | Homo sapiens | GSE45982 | 22,729 | |||
| EZH2 | LNCaP | GEO | Homo sapiens | GSE39459 | 48,376 | |||
| EZH2 | WA01 | ENCODE | Homo sapiens | ENCSR000ASY | 13,462 | |||
| EZH2 | phosphoT487 | SU-DHL-6 | ENCODE | Homo sapiens | ENCSR088HZI | 1,722 | ||
| EZH2 | SU-DHL-6 | ENCODE | Homo sapiens | ENCSR090TRI | 279 | |||
| EZH2 | phosphoT487 | SK-N-SH | ENCODE | Homo sapiens | ENCSR297MUV | 2,493 | ||
| EZH2 | PC-9 | ENCODE | Homo sapiens | ENCSR793USK | 29,482 | |||
| EZH2 | phosphoT487 | PC-9 | ENCODE | Homo sapiens | ENCSR702GMW | 52,337 | ||
| EZH2 | phosphoT487 | PC-3 | ENCODE | Homo sapiens | ENCSR617RSQ | 7,312 | ||
| EZH2 | phosphoT487 | OCI-Ly7 | ENCODE | Homo sapiens | ENCSR565XSL | 7,106 | ||
| EZH2 | phosphoT487 | OCI-Ly3 | ENCODE | Homo sapiens | ENCSR584ATA | 268 | ||
| EZH2 | K-562 | ENCODE | Homo sapiens | ENCSR000AQE | 1,792 | |||
| EZH2 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000ARI | 8,716 | |||
| EZH2 | phosphoT487 | GM23338 | ENCODE | Homo sapiens | ENCSR591DTH | 1,205 | ||
| EZH2 | GM23338 | ENCODE | Homo sapiens | ENCSR045YHA | 8,815 | |||
| EZH2 | GM23248 | ENCODE | Homo sapiens | ENCSR131FFJ | 6,919 | |||
| EZH2 | phosphoT487 | GM23248 | ENCODE | Homo sapiens | ENCSR096KPA | 15,674 | ||
| EZH2 | A-673 | ENCODE | Homo sapiens | ENCSR179SAO | 11,175 | |||
| EZH2 | neural | progenitor | ENCODE | Homo sapiens | ENCSR069DPL | 9,150 | ||
| EZH2 | neural | ENCODE | Homo sapiens | ENCSR511CUH | 3,408 | |||
| EZH2 | phosphoT487 | neural | progenitor | ENCODE | Homo sapiens | ENCSR656MXA | 8,381 | |
| EZH2 | myotube | ENCODE | Homo sapiens | ENCSR000ASZ | 4,640 | |||
| EZH2 | myoblast | skeletal_muscle | ENCODE | Homo sapiens | ENCSR000ARH | 1,180 | ||
| EZH2 | phosphoT487 | Loucy | ENCODE | Homo sapiens | ENCSR783QUL | 1,009 | ||
| EZH2 | HUVEC-C | VEGF_12h | GEO | Homo sapiens | GSE109625 | 4,483 | ||
| EZH2 | HUVEC-C | GEO | Homo sapiens | GSE109625 | 6,276 | |||
| EZH2 | HUVEC-C | VEGF_4h | GEO | Homo sapiens | GSE109625 | 3,595 | ||
| EZH2 | HUVEC-C | VEGF_1h | GEO | Homo sapiens | GSE109625 | 5,076 | ||
| EZH2 | keratinocyte | ENCODE | Homo sapiens | ENCSR000ARK | 9,051 | |||
| EZH2 | KARPAS422 | ENCODE | Homo sapiens | ENCSR646CKG | 153 | |||
| EZH2 | hepatocyte | ENCODE | Homo sapiens | ENCSR384LYW | 5,095 | |||
| EZH2 | phosphoT487 | hepatocyte | ENCODE | Homo sapiens | ENCSR341VYI | 19,012 | ||
| EZH2 | GM12878 | ENCODE | Homo sapiens | ENCSR000ARD | 83 | |||
| EZH2 | fibroblast | LUNG | ENCODE | Homo sapiens | ENCSR000ARO | 8,264 | ||
| EZH2 | fibroblast | DERMAL | ENCODE | Homo sapiens | ENCSR000ASE | 5,318 | ||
| EZH2 | epithelial | mammary | ENCODE | Homo sapiens | ENCSR000ARE | 5,743 | ||
| EZH2 | endothelial | umbilical-vein | ENCODE | Homo sapiens | ENCSR000ATA | 6,447 | ||
| EZH2 | phosphoT487 | DOHH2 | ENCODE | Homo sapiens | ENCSR562NOP | 4,828 | ||
| EZH2 | DND41 | ENCODE | Homo sapiens | ENCSR000ASW | 46,175 | |||
| EZH2 | astrocyte | ENCODE | Homo sapiens | ENCSR000ARR | 12,993 | |||
| EZH2 | RH30 | DMSO | GEO | Homo sapiens | GSE85169 | 56,587 | ||
| EZH2 | RH30 | Trametinib | GEO | Homo sapiens | GSE85169 | 360 | ||
| EZH2 | hESC | KO | GEO | Homo sapiens | GSE113817 | 3,334 | ||
| EZH2 | hESC | GEO | Homo sapiens | GSE113817 | 5,453 | |||
| EZH2 | hESC | GEO | Homo sapiens | GSE13084 | 119 | |||
| EZH2 | T98G | GEO | Homo sapiens | GSE112240 | 18,557 | |||
| EZH2 | KG-1 | shPLZF | GEO | Homo sapiens | GSE109619 | 2,733 | ||
| EZH2 | ProEs | GEO | Homo sapiens | GSE59087 | 8,046 | |||
| EZH2 | ProEs | SHCTR | GEO | Homo sapiens | GSE59087 | 7,582 | ||
| EZH2 | ProEs | SHEZH2 | GEO | Homo sapiens | GSE59087 | 214 | ||
| EZH2 | hiPSC | WTa_RNase-neg | GEO | Homo sapiens | GSE128135 | 280 | ||
| EZH2 | dermal-fibroblast | Preneoplastic | GEO | Homo sapiens | GSE126396 | 7,412 | ||
| EZH2 | dermal-fibroblast | Transformed | GEO | Homo sapiens | GSE126396 | 14,810 | ||
| EZH2 | dermal-fibroblast | Untransformed | GEO | Homo sapiens | GSE126396 | 17,454 | ||
| EZH2 | prostate-cancer | HA | GEO | Homo sapiens | GSE107780 | 32,503 | ||
| EZH2 | prostate-cancer | shEZH2 | GEO | Homo sapiens | GSE107780 | 8,737 | ||
| EZH2 | prostate-cancer | plko | GEO | Homo sapiens | GSE107780 | 15,828 | ||
| EZH2 | Hep-3B2-1-7 | GEO | Homo sapiens | GSE128137 | 23,129 | |||
| EZH2 | HCT-116 | ENCODE | Homo sapiens | ENCSR046HGP | 38,389 | |||
| EZH2 | phosphoT487 | HCT-116 | ENCODE | Homo sapiens | ENCSR429CLV | 6,829 | ||
| EZH2 | B-cell | ENCODE | Homo sapiens | ENCSR000AUZ | 4,256 | |||
| EZH2 | peripheral-blood-mononuclear-cell | GEO | Homo sapiens | GSE115772 | 10,940 | |||
| EZH2 | peripheral-blood-mononuclear-cell | mut | GEO | Homo sapiens | GSE115772 | 16,838 | ||
| EZH2 | peripheral-blood-mononuclear-cell | B-cell | GEO | Homo sapiens | GSE115772 | 4,824 | ||
| EZH2 | phosphoT487 | neuron | bipolar_doxy_4d | ENCODE | Homo sapiens | ENCSR886KKK | 19,181 | |
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |