FGFR1

Information FGFR1

Description

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity). {ECO:0000250|UniProtKB:P11362, ECO:0000269|PubMed:10821861, ECO:0000269|PubMed:10896947, ECO:0000269|PubMed:1309590, ECO:0000269|PubMed:17086194, ECO:0000269|PubMed:8001822, ECO:0000269|PubMed:8001823}.(Source UnitProtKB).

Full Name

fibroblast growth factor receptor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
43,743
Non-redundant peaks
43,743

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14182
Official Gene Name
Fgfr1
JASPAR
MGI
MGI:95522
Ensembl
ENSMUSG00000031565
UniProt
P16092
Genevisible
P16092
RefSeq
NM_010206
Aliases
AW208770; Eask; FGFR-I; FLG; Fgfr-1; Flt-2; Fr1; Hspy; MFR; bFGF-R-1; c-fgr
All peaks FGFR1
Download BED file
Non redundant peaks FGFR1
Download BED file
SEQUENCES FGFR1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for FGFR1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
FGFR1 mESC LIF GEO Mus musculus GSE65695 43,743
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks