FOS

Information FOS

Description

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000250, ECO:0000269|PubMed:12134156, ECO:0000269|PubMed:12972619, ECO:0000269|PubMed:15719069, ECO:0000269|PubMed:21998197, ECO:0000269|PubMed:22105363}.(Source UnitProtKB).

Full Name

FBJ osteosarcoma oncogene

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
25
Biotypes
7
Peaks
825,602
Non-redundant peaks
233,503

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14281
Official Gene Name
Fos
JASPAR
MGI
MGI:95574
Ensembl
ENSMUSG00000021250
UniProt
P01101
Genevisible
P01101
RefSeq
NM_010234
Aliases
D12Rfj1; c-fos; cFos

External links
All peaks FOS
Download BED file
Non redundant peaks FOS
Download BED file
SEQUENCES FOS
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for FOS

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
FOS primary-fibroblast GEO Mus musculus GSE83295 4,226
FOS primary-fibroblast 90min_KO GEO Mus musculus GSE83295 368
FOS cortical-neuron FOS-ShRNA GEO Mus musculus GSE60192 3,701
FOS cortical-neuron KCl_ab2 GEO Mus musculus GSE60192 38,869
FOS cortical-neuron KCl GEO Mus musculus GSE60192 21,662
FOS cortical-neuron ab2 GEO Mus musculus GSE60192 517
FOS macrophage KLA-1h GEO Mus musculus GSE111854 67,725
FOS macrophage KLA-1h_BL6 GEO Mus musculus GSE111854 36,539
FOS mESC mesenchymal GEO Mus musculus GSE88986 15,846
FOS TSC differentiated GEO Mus musculus GSE110950 71,149
FOS BMDM 30min GEO Mus musculus GSE99895 69,702
FOS BMDM KLA-6h GEO Mus musculus GSE72964 46,060
FOS BMDM veh-6h GEO Mus musculus GSE72964 41,154
FOS BMDM 1h GEO Mus musculus GSE99895 77,839
FOS BMDM 2h GEO Mus musculus GSE99895 70,727
FOS BMDM 0min GEO Mus musculus GSE99895 45,671
FOS BMDM GEO Mus musculus GSE72964 28,838
FOS BMDM 15min GEO Mus musculus GSE99895 43,361
FOS hematopoietic-cell min-Dox GEO Mus musculus GSE79320 16,596
FOS BMDM homog-6h GEO Mus musculus GSE72964 54,697
FOS TSC GEO Mus musculus GSE110950 2,723
FOS macrophage veh_BL6 GEO Mus musculus GSE111854 8,037
FOS macrophage veh GEO Mus musculus GSE111854 23,724
FOS cortical-neuron ctrl-ShRNA GEO Mus musculus GSE60192 32,818
FOS cortical-neuron GEO Mus musculus GSE60192 3,053
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks